Results 81 to 90 of about 1,381,560 (302)

Ultrasonic-assisted Lossen rearrangment of N-phenylsulfonyloxy succinimide: synthesis, and in silico ADME predictions pharmacokinetics, and druglikenes of 3-ureidopropanamide derivatives & pyrimidine-2,4-diol derivative

Discover Chemistry
N-phenylsulfonyloxy succinimide 2 was synthesized in 75% yield and used as a building block in the synthesis of N,N ’ -disubstituted urea derivatives. Sonication of compound 2 with amines namely propylamine, allylamine, aniline and hydrazine in one-pot ...
Mahmoud Farouk, Salman A. H. Alrokayan, Ahamad Imran, Salsabil Mahmoud, Sama Mahmoud   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Drug-likeness (Lipinski rule of five) for XL765 and the six proposed dual inhibitors 28, 18, 38, 9, 10, and 19.

, 2019
Drug-likeness (Lipinski rule of five) for XL765 and the six proposed dual inhibitors 28, 18, 38, 9, 10, and 19.
Mohd Rehan (198120)
core   +1 more source

ADMET-informatics, Pharmacokinetics, Drug-likeness and Medicinal Chemistry of Bioactive Compounds of Physalis minima Ethanolic Leaf Extract (PMELE) as a Potential Source of Natural Lead Molecules for Next Generation Drug Design, Development and Therapies

, 2022
Physalis minima (PM) belongs to the family Solanaceae. PM has been traditionally used to cure and prevent several disorders as documented in Vedic Texts. Nevertheless, scientific values of traditional claims haven\u27t been explored yet.
Priyanka, R., Loganathan, T., Pandiarajan, G., Sutha, S., Chandran, M., Abraham, GC., Jayakumararaj, R., Grace Lydial Pushpalatha, G, Ramya, S., Kaliraj, P.   +9 more
core   +2 more sources

Angular Phenozaxine Ethers as Potent Multi-microbial Targets Inhibitors: Design, Synthesis, and Molecular Docking Studies

Frontiers in Chemistry, 2017
The reaction of diaza-5H-benzo[a]phenoxazin-5-one and 5H-benzo[a]phenoxazin-5-one with various phenols catalyzed by Pd/t-BuXPhos/K3PO4 system gave previously unknown ether derivatives (7a–f and 8a–f) in good yields. UV-visible, FTIR, and 1H NMR data were
Mercy A. Ezeokonkwo, Onyinyechi N. Ogbonna, Sunday N. Okafor, Evelyn U. Godwin-Nwakwasi, Fidelia N. Ibeanu, Uchechukwu C. Okoro   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Drug-likeness evaluation of the six dual-active alkaloids.

Drug-likeness evaluation of the six dual-active alkaloids.
Iqra Ahmad (17471892), Haq Nawaz (63419), Sheheryar (12259148), Mohibullah Shah (1590358), Riaz Ullah (5547797), Ke Chen (73307), Amen Shamim (10008107), Essam A. Ali (14000319), Umar Nishan (571108), Gang Wu (23885), Ramsha Yamin (17768636), Zainab Jahangir (17768639)   +11 more
core   +1 more source

Molecular docking and prediction of ADME/drug-likeness properties of potentially active antidiabetic compounds isolated from aqueous-methanol extracts of Gymnema sylvestre and Combretum micranthum

, 2021
Gymnema sylvestre and Combretum micranthum are well known for their ethno-medicinal uses in the northwest of Nigeria. In our recent study, we demonstrated the antidiabetic and antioxidant activities of the aqueous-me¬thanol extracts of the two plants and
Ononamadu, C.J., Ibrahim, A., Chimaobi Ononamadu, Aminu Ibrahim   +3 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

GPT like transformer based conditional molecule generator and a high drug-likeness (QED) dataset generation

This study presents the development and evaluation of a novel GPT-like conditional molecule generator designed to optimize the synthesis of chemical compounds with desirable properties.
Juan , Yang, Wen, Xing
core   +1 more source