Results 121 to 130 of about 2,984,799 (310)

HGF/c‐Met Axis‐Targeted Nanotherapy via GSH‐Responsive Polymer Platforms Suppresses Uveal Melanoma Metastasis

open access: yesAdvanced Healthcare Materials, EarlyView.
To suppress uveal melanoma metastasis (UM), the GSH‐responsive polymer named NP@Oxa/Criz has been successfully prepared. NP@Oxa/Criz selectively accumulates in UM tumors, targeting HGF/c‐Met Axis to undermine the stemness and metastasis of UM while triggering immunogenic cell death through DAMPs release to boost anti‐tumor immunity.
Hui Tao   +8 more
wiley   +1 more source

A Prospective Analysis of Adverse Drug Reactions in a South Indian Hospital [PDF]

open access: yes, 2009
Adverse drug reactions are a great cause of concern to the medical profession, the patients and the pharmaceutical industry. However ADR reporting and monitoring is yet to catch up in India.
Adhikari, P, Padmaja, U, Pereira, P
core  

Assessing Response Rates and Sleep Disorder Prevalence: Insights from a Propranolol Treatment Study for Infantile Haemangiomas [PDF]

open access: yes
Background: Infantile haemangiomas (IHs) sometimes require treatment with propranolol. Sleep disturbances are the most frequently reported side effects. Monitoring adverse drug events necessitates repeated hospital visits, which can be challenging during
Opri, Francesca   +3 more
core   +1 more source

Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons

open access: yesAdvanced Healthcare Materials, EarlyView.
This study introduces a novel chitosan‐based nanocarrier functionalized with a neurotropic protein for efficient siRNA delivery to neurons. The polyplexes demonstrate enhanced neuronal binding, retrograde transport, and PTEN silencing, promoting axonal outgrowth.
Ana P. Spencer   +10 more
wiley   +1 more source

New drugs on the Internet : the case of Camfetamine [PDF]

open access: yes, 2014
Copyright © 2014 Eduardo Cinosi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Acciavatti, Tiziano   +6 more
core   +2 more sources

Fabrication of a Lipopolysaccharide‐Targeting Peptide‐Based Colloid for Alleviating Carbapenem‐Resistant Enterobacteriaceae‐Induced Cutaneous Infection

open access: yesAdvanced Healthcare Materials, EarlyView.
In this study, a novel cationic peptide, IW is designed and synthesized, with a tandem‐repeat sequence demonstrating potent activities against a broad spectrum of clinically relevant Carbapenem‐resistant Enterobacteriaceae in both the planktonic and biofilm states. IW is then formulated with P407 to form IW‐P407 colloids.
Ping Zeng   +5 more
wiley   +1 more source

Newer drugs for focal epilepsy in adults [PDF]

open access: yes, 2012
A 28 year old woman sees her general practitioner after experiencing what sounds like a convulsion without any apparent provoking factor. Over the past month she has also had “blank spells” during which her husband noticed her to be unresponsive.
Brodie, M., Kwan, P.
core   +1 more source

Albumin Corona Overturns Long‐Acting Behaviors of Myristic Acid‐Conjugated Quetiapine Nanosuspension

open access: yesAdvanced Healthcare Materials, EarlyView.
Albumin corona alters surface properties and enhances colloidal stability by overturning pH responsiveness and nano‐aggregation behaviors of long‐acting myristic acid‐conjugated quetiapine nanosuspensions (QMN), resulting in accelerated in vitro and in vivo drug release.
Hy Dinh Nguyen   +2 more
wiley   +1 more source

Acute renal and neurotoxicity due to weight-based dosing of intravenous acyclovir: How to dose in obese patients?

open access: yesClinical Infection in Practice, 2020
Background: Acyclovir is a hydrophilic drug that is mainly distributed in the lean compartments of the body. Consequently, dosing on total body weight in obese patients may lead to drug overdosing.
Bastiaan TGM Sallevelt   +4 more
doaj  

Comparison of algorithms that detect drug side effects using electronic healthcare databases [PDF]

open access: yesarXiv, 2014
The electronic healthcare databases are starting to become more readily available and are thought to have excellent potential for generating adverse drug reaction signals. The Health Improvement Network (THIN) database is an electronic healthcare database containing medical information on over 11 million patients that has excellent potential for ...
arxiv  

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