Results 121 to 130 of about 143,950 (267)

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Antibiotic adverse reactions and drug interactions

, 2008
Each year many patients are hospitalized with adverse drug reactions. Life-threatening reactions include arrhythmias, hepatotoxicity, acute renal failure, and antiretroviral therapy-induced lactic acidosis.
Granowitz, Eric, MD, MD Eric V Granowitz, Brown, Richard, MD, MD Richard B Brown   +3 more
core  

To Study Adverse Drug Reactions in MDR Pulmonary Tuberculosis Patients

, 2021
Aim: To Study Adverse Drug Reactions In MDR Pulmonary Tuberculosis Patients. Methods: The Prospective Observational Study was carried out on patients of MDR/XDR Pulmonary Tuberculosis, registered at DR-TB Centre attended in OPD or admitted in DOTS Plus ...
Pankaj Panchal, Harsha Hanji, Shrikant Hiremath, Monika Keena, Geetanjali Hiremath   +4 more
core  

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

How safe are herbal products? [PDF]

, 2000
In the search for cures for his ailments, man discovered many healing and toxic properties of plants. Some were found to cure certain diseases while others were found to exert dramatic effects on the body.
Forte, John Stephen
core  

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Propofol-Associated Seizure-Like Phenomenon During Anesthetic Induction: A Case Report

Bali Journal of Anesthesiology
Propofol is a widely used intravenous anesthetic agent known for its anticonvulsant properties and off-label use in refractory status epilepticus. However, paradoxical excitatory manifestations, collectively termed seizure-like phenomena (SLP), have been
Sherrie Mae Valencia Bautista
doaj   +1 more source

Treatments used in complementary and alternative medicine

, 2011
Pharmacovigilance in complementary and alternative medicine. Pharmacovigilance in complementary and alternative medicine has attracted much attention worldwide.
Chan, Kelvin (R15157), Lin, Z. X., Zhang, Hongwei   +2 more
core   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Antibiotic-induced adverse drug reactions: investigating the utility of routinely collected data

Adverse drug reactions (ADRs) are defined as a noxious response to a medicinal product where a causal relationship between the medicinal product and an adverse event is either known or strongly suspected. ADRs account for 16.5% of UK hospital admissions,
Dixon, Eleanor G.
core   +1 more source