Results 171 to 180 of about 310,100 (285)

Optimization of the Isolation Method for Large‐Scale Production of Synthetic Bacterial Vesicles for Cancer Immunotherapy

Advanced Therapeutics, EarlyView.
This study introduces a reliable technique for the large‐scale production of bacterial vesicles that maintain their immune‐modulating potential, enabling industrial manufacturing and clinical applications. Although other cancer immunotherapies are available, this research presents an advanced bacterial vesicle‐based therapeutic option, with scalable ...
Negar Ordouzadeh, Rossella Crescitelli, Agnes Zimmer, Petra Tjärnlund, Cecilia Lässer, Jan Lötvall, Kyong‐Su Park   +6 more
wiley   +1 more source

Effect of <i>CYP1A2</i>, <i>CYP2D6</i>, and <i>CYP3A4</i> Variation on Antipsychotic Treatment Outcomes. [PDF]

Pharmaceuticals (Basel)
Varney L, Murtough S, Cotic M, Abidoph R, Chan L, Saadullah Khani N, Richards-Belle A, Richards-Brown M, Mills D, Panconesi D, Dawda Y, Sharma P, Shah C, Secchi A, Nilforooshan R, Mudholkar S, Murdoch R, Molai J, Griffiths R, Senthilkumar S, Blake H, Lankshear S, McRoberts J, Pastor B, Thomas C, Richards S, Welfare-Wilson A, Cheung SB, Cox R, Jibero AC, Anad R, Laczik R, Ghali S, Berry AJ, Curwen J, Odutoye K, Kottalgi G, Williams S, Wong S, Anandan N, Pius G, Ajiteru T, Clark V, van Driel P, Bashir A, Court S, Pawsey M, Skowronska A, Woodley J, Bramon E.   +49 more
europepmc   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Safety of Proton Pump Inhibitor in Paediatrics: A Study Based on EudraVigilance Data. [PDF]

Fundam Clin Pharmacol
Santi Laurini G, Nikitina V, Montanaro N, Motola D.   +3 more
europepmc   +1 more source

Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice

Advanced Science, EarlyView.
This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.
Xianyun Wang, Dajun Li, Xiao Ying Li, Weizhao Lu, Huini Ding, Chengyan Qi, Xuan Wang, Jing Shen, Yafei Chi, Tiantian Li, Michelle M. Dunk, Yu An, Hongmei Huang, Kang Yu, Weili Xu, Rong Xiao, Yuandi Xi   +16 more
wiley   +1 more source

Nanomaterials and immune checkpoint inhibitors in cancer immunotherapy: the synergistic innovation prospects. [PDF]

Front Immunol
Chen J, Cheng X.
europepmc   +1 more source

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

Advanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou, Xin‐Ge Wang, Xuan‐Ren Shi, Shu‐Ting Sun, Jing Mi, Xiao‐Peng Zhang, Bin‐Cheng Yin, Ying Zhou, Bang‐Ce Ye   +8 more
wiley   +1 more source

Drugs and Healthy Aging. [PDF]

Drugs Aging
Hilmer SN, Ferrucci L, Cherubini A.
europepmc   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

The Adverse Effects of Tuberculosis Treatment: A Comprehensive Literature Review. [PDF]

Medicina (Kaunas)
Mereškevičienė R, Danila E.
europepmc   +1 more source