Results 211 to 220 of about 310,100 (285)

Real-world insights into safety, tolerability, and predictive factors of adverse drug reactions in treating idiopathic pulmonary fibrosis with pirfenidone and nintedanib. [PDF]

Ther Adv Drug Saf
Provenzani A, Leonardi Vinci D, Alaimo M, Di Maria S, Tuzzolino F, Floridia G, Di Stefano R, Carollo A, Callari A, Polidori P, Vitulo P.   +10 more
europepmc   +1 more source

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source

Adverse event profile differences among long-acting gonadotropin-releasing hormone analogs: A real-world, pharmacovigilance study. [PDF]

PLoS One
Chen Y, Lu W, Liao R, Zhang X, Chen W, Wang J, Feng H.   +6 more
europepmc   +1 more source

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

Advanced Science, EarlyView.
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang, Shuaiyang Jing, Haojun Li, Bao Xiao, Jiahui Jin, Xiu Sun, Juan Wang, Jing Liang, Tongze Cai, Huili Hu, Meilan Wei, Xuanrui Zhong, Yang Ji, Peng George Wang, Jianlong Zhou   +14 more
wiley   +1 more source

Understanding side effects of psychotherapies: implications for clinical practice and research trials. [PDF]

World Psychiatry
O'Neil A, Rossell SL, Berk M.
europepmc   +1 more source

Incentivizing Postmarketing Pharmaceutical Product Safety Testing with Extension of Exclusivity Periods [PDF]

, 2008
Kushner, Leslie
core   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

A retrospective observational study on case reports of adverse drug reactions (ADRs) to tirzepatide. [PDF]

Front Pharmacol
Huang M, Liu G, Zhang C, Wang Y, Liu S, Zhao J.   +5 more
europepmc   +1 more source

In Situ Proliferating Peptide Nanoparticle Augments Multi‐Target Intervention of Secondary Brain Damage Following Subarachnoid Hemorrhage

Advanced Science, EarlyView.
This work designs an in situ proliferating peptide nanoparticle as a flexible resolution that modulates the neuro‐glia unit to enable enhanced multi‐target combinational therapy for secondary brain damage following subarachnoid hemorrhage. Abstract Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered ...
Yibin Zhang, Peisen Yao, Fuxiang Chen, Shufa Zheng, Xuegang Niu, Haojie Wang, Yuanxiang Lin, Bin Gao, Dezhi Kang   +8 more
wiley   +1 more source

Efficacy of Baclofen as Add-on Therapy for Refractory Gastroesophageal Reflux Disease: A Meta-analysis. [PDF]

J Clin Gastroenterol
Dong H, Luo Y, Liu D, Du X, Du H.
europepmc   +1 more source