Results 231 to 240 of about 311,418 (261)

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

A scoping review of interventions to prevent and treat adverse events during treatment of rifampin-susceptible tuberculosis. [PDF]

PLoS One
Burman WJ, Martins MF, Flynn D, Johnston J, Sinha P, Horsburgh CR.   +5 more
europepmc   +1 more source

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

Advanced Science, EarlyView.
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui, Jingwei Wang, Xiaoyun Li, Lina Wang, Xuehan Mao, Rui Lyv, Wenqiang Yan, Jingyu Xu, Jieqiong Zhou, Chenxing Du, Shuhui Deng, Mu Hao, Yan Xu, Shuhua Yi, Dehui Zou, Tao Cheng, Xin Gao, Lugui Qiu, Gang An   +18 more
wiley   +1 more source

Management of adverse reactions to targeted therapy and immunotherapy for pancreatic cancer: A literature review. [PDF]

J Int Med Res
Huang F, Huang ZP.
europepmc   +1 more source

Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention

Advanced Science, EarlyView.
This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi, Lu Bian, Mengyuan Yu, Jun Wang, Mingzhu Gao, Liping Shen, Xiao Zhang, Zhiliang Huang, Hong Tang, Long Lv, Yunduan Que, Zengli Miao, Xuechao Wu, Qing Wang, Xiaojie Lu   +14 more
wiley   +1 more source

Data Mining of Adverse Reactions to Iodinated Contrast Media Based on a Municipal Spontaneous Reporting System in China. [PDF]

Curr Med Sci
Zhang WT, Li WJ, Zhang JW, Shu YM, Leng YH, Xu RX, Li Q, Cui QH, Gong XP, Liu D, Jiang Y.   +10 more
europepmc   +1 more source

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

Advanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou, Zhenfei Zhong, Peng Hu, Weigang Wang, Ying Song, Na Yang, Fangyan He, Yajie Li, Qi Sa, Yanmei Yang, Qinmiao Sun, Tonghua Yang, Beibei Zhang, Dahua Chen   +13 more
wiley   +1 more source

The clinical application progress of multimodal analgesia strategy in enhanced recovery after surgery: a narrative review. [PDF]

Front Pain Res (Lausanne)
Yang L, Lou W, Jiang Y, Yang L, Wang D, Wang J.   +5 more
europepmc   +1 more source

The Efficacy of Combined Lamotrigine and Levetiracetam Therapy in Epileptic Patients and Its Effects on Hippocampal Volume and Neuroinflammatory Response. [PDF]

J Inflamm Res
Li P, Qi A, Ma J, Li A, Sun Z.
europepmc   +1 more source

Prescribing Patterns and Adverse Reactions of Antipsychotics in a North Indian Psychiatry Outpatient Department. [PDF]

Cureus
Sodhi S, Singh H, Sharma AK, Mina S, Gupta S, Vadanere NP.   +5 more
europepmc   +1 more source