Results 211 to 220 of about 401,503 (258)

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

AI-Driven Design of High Affinity Biomolecule-Drug Conjugates for Gynecological Cancer Therapy: An Up-to-Date Narrative Review. [PDF]

Cancers (Basel)
Garg P, Horne D, Salgia R, Singhal SS.
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Drug Safety Assessment Based on Target Affinity, Drug Exposure and Plasma Protein Binding: Drug-Induced Cardiotoxicity from a Translational Pharmacology Perspective. [PDF]

Int J Mol Sci
Catozzi S, Sips F, Totis N, Bisotti MA, Stathopoulos S, Torchia M, Emili L, Carbone V, Baker C, Mahoney JM, Röshammar D, Cardioverse Project Team.   +11 more
europepmc   +1 more source

A multi-target drug design method based on target feature fusion. [PDF]

BMC Bioinformatics
Liu H, Lin X, Hu J, Zhang X.
europepmc   +1 more source

Deep Drug–Target Binding Affinity Prediction Base on Multiple Feature Extraction and Fusion

ACS Omega
Zepeng Li, Yuni Zeng, Mingfeng Jiang, Bo Wei   +3 more
doaj   +1 more source

DrugForm-TAS: Target-Agnostic Selectivity as Proteome-wide Binding Propensity Estimation. [PDF]

Comput Struct Biotechnol J
Tashchilova A, Khokhlov I, Seikin A, Bugaev-Makarovskiy N, Glushkova O, Yudin V, Keskinov A, Yudin S, Svetlichnyy D, Skvortsova V.   +9 more
europepmc   +1 more source

GraphDTA for predicting drug–target binding affinity

openaire   +1 more source

Beyond the canonical: The role of post-transcriptional regulation in drug-target interaction prediction. [PDF]

PLoS Comput Biol
Ansari MI, Ahmed KT, Wang DD, Medvedev K, Zhang W.   +4 more
europepmc   +1 more source