Results 81 to 90 of about 4,932,082 (261)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Drug-target-PPI associations for HMI.

, 2022
(A) Relationship between anti-HMI drug candidates and HMI-associated PPIs. Top 10 PPIs with the highest number of shortest links to drug targets are shown (one PPI may correspond to multiple targets). (B) Closest PPIs regulated by raloxifene. (C) Closest
Yao Jiang (1469614), Jia-Xuan Zhang (14279440), Rong Liu (202610)   +2 more
core   +1 more source

Stereochemistry-Aware Drug-Target Affinity Prediction

Abstract Drug–target affinity (DTA) prediction is a key task in drug discovery, enabling the estimation of the interaction strength between candidate compounds and biological targets. However, current models rely on connectivity-based molecular representations and do not explicitly account for the spatial organization, also known as ...
Santiago Ferreyra, Iago Dutra, Aldo Galeano, Alberto Paccanaro   +3 more
openaire   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Drug-target-PPI associations for MHCI.

, 2022
(A) Relationship between anti-MHCI drug candidates and MHCI-associated PPIs. Top 10 PPIs with the highest number of shortest links to drug targets are shown (one PPI may correspond to multiple targets).
Yao Jiang (1469614), Jia-Xuan Zhang (14279440), Rong Liu (202610)   +2 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Drug-target-PPI associations for MMI.

, 2022
(A) Relationship between anti-MMI drug candidates and MMI-associated PPIs. Top 10 PPIs with the highest number of shortest links to drug targets are shown (one PPI may correspond to multiple targets). (B) Closest PPIs regulated by azithromycin.
Yao Jiang (1469614), Jia-Xuan Zhang (14279440), Rong Liu (202610)   +2 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Multimodal Cross-scale Feature Fusion for Drug-Target Affinity Prediction

Zhengzhou Daxue xuebao. Gongxue ban
To address the current challenges of relying solely on single-modal features of target proteins and neglecting network-scale features in biological networks, a drug-target affinity prediction (DTA) model based on multimodal cross-scale feature fusion ...
ZHENG Hong , LUO Yujian, LING Kan, FAN Guisheng   +3 more
doaj   +1 more source