Results 61 to 70 of about 6,076,909 (260)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Local and global modes of drug action in biochemical networks [PDF]

, 2008
It becomes increasingly accepted that a shift is needed from the traditional target-based approach of drug development to an integrated perspective of drug action in biochemical systems. We here present an integrative analysis of the interactions between
Schwartz, Jean Marc; id_orcid, Jean-Marc Schwartz, Nacher, Jose C., Jose C. Nacher, Jose C Nacher   +4 more
core   +1 more source

GraphCL-DTA: a graph contrastive learning with molecular semantics for drug-target binding affinity prediction [PDF]

, 2023
Drug-target binding affinity prediction plays an important role in the early stages of drug discovery, which can infer the strength of interactions between new drugs and new targets. However, the performance of previous computational models is limited by
Chu, Jian, Yang, Genke, Yang, Xinxing
core   +1 more source

Multimodal Cross-scale Feature Fusion for Drug-Target Affinity Prediction

Zhengzhou Daxue xuebao. Gongxue ban
To address the current challenges of relying solely on single-modal features of target proteins and neglecting network-scale features in biological networks, a drug-target affinity prediction (DTA) model based on multimodal cross-scale feature fusion ...
ZHENG Hong , LUO Yujian, LING Kan, FAN Guisheng   +3 more
doaj   +1 more source

ELECTRA-DTA: a new compound-protein binding affinity prediction model based on the contextualized sequence encoding

Journal of Cheminformatics, 2022
Motivation Drug-target binding affinity (DTA) reflects the strength of the drug-target interaction; therefore, predicting the DTA can considerably benefit drug discovery by narrowing the search space and pruning drug-target (DT) pairs with low binding ...
Junjie Wang, NaiFeng Wen, Chunyu Wang, Lingling Zhao, Liang Cheng   +4 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Villemaine Estelle, Brendan D Galvin, Wyatt, Paul G., Zhiru Li, Estelle Villemaine, Brendan D. Galvin (592211), Carlow, Clotilde K. S., Wyatt Paul G., Zhiru Li (295010), Poole Catherine B., Li, Zhiru, Carlow Clotilde K. S., Michael P. Pollastri (345704), Clotilde K S Carlow, Michael P Pollastri, Li Zhiru, Chapman Melissa S., Melissa S. Chapman (625936), Melissa S Chapman, Chapman, Melissa S., Pollastri, Michael P., Clotilde K. S. Carlow (111245), Catherine B. Poole (111223), Paul G. Wyatt (473658), Pollastri Michael P., Poole, Catherine B., Catherine B Poole, Galvin, Brendan D., Villemaine, Estelle, Paul G Wyatt, Galvin Brendan D., Estelle Villemaine (625935)   +31 more
core   +2 more sources

Stereochemistry-Aware Drug-Target Affinity Prediction

Abstract Drug–target affinity (DTA) prediction is a key task in drug discovery, enabling the estimation of the interaction strength between candidate compounds and biological targets. However, current models rely on connectivity-based molecular representations and do not explicitly account for the spatial organization, also known as ...
Santiago Ferreyra, Iago Dutra, Aldo Galeano, Alberto Paccanaro   +3 more
openaire   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source