Results 111 to 120 of about 5,903,465 (247)
DTA Atlas: A massive-scale drug repurposing database
Artificial Intelligence in the Life SciencesThe drug development process is costly and time-consuming. Repurposing existing approved drugs, an efficient and cost-effective strategy, involves assessing numerous drug-protein pairs to uncover new interactions.
Madina Sultanova +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
The Trypanosoma brucei sphingolipid synthase, an essential enzyme and a drug target [PDF]
, 2009 Sphingolipids are important structural components of eukaryotic membranes, in addition they and their precursors are involved in signal transduction processes.
Pan, Ssu-Ying
core
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu +10 more
wiley +1 more source
Prediction of Drug-Target Binding Affinity: A Regression Approach for IC50Prediction
, 2023 Since ancient times, humans have sought to combat disease through drug administration. As Science has evolved, Drug Discovery (DD) has led industries to focus solely on the production of pharmaceutical products. Currently, the pharmaceutical industry struggles to find new pharmaceutical products; however, this is becoming an increasingly difficult task
openaire +1 more source
Electrospun Wood‐Derived Biopolymers as Electrodes in Electrochemical Energy Storage Technologies
Advanced Functional Materials, EarlyView.Electrospinning transforms wood‐derived cellulose and lignin into architecturally defined, binder‐free carbon electrodes with tuneable porosity and functionality. This review shows how fibre design enables decoupled charge and mass transport, enhancing performance across battery systems, while identifying key challenges in spinnability, scalability ...
Michael W. Thielke +3 more
wiley +1 more source
Journal of Pharmaceutical AnalysisAffinity selection mass spectrometry (AS-MS) has emerged as a powerful label-free technique for identifying and characterizing ligand-target interactions.
Pamella Christina Ortega de Oliveira +4 more
doaj +1 more source
DataDTA: a multi-feature and dual-interaction aggregation framework for drug-target binding affinity prediction. [PDF]
Bioinformatics, 2023 Zhu Y, Zhao L, Wen N, Wang J, Wang C.
europepmc +1 more source