Results 221 to 230 of about 342,422 (269)

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Polar Lattice‐Distorted Motifs Enable Synergy of Local Polarization/Dipole Fields for Concurrent Glyphosate Wastewater Remediation and CO Evolution

Advanced Science, EarlyView.
Photocatalytic treatment of glyphosate herbicide in agricultural wastewater is achieved through the cooperative effect of the local polarization field and dipole field mediated by lattice‐distorted carbon nitride. Glyphosate is completely degraded via selective C─P bond cleavage with a CO evolution rate of 1166 µmol g−1 h−1.
Daoping Chen, Huan Liu, Tengyu Liu, Jie Li, Qizhi Luo, Yan Zhang, Shengkun Li, Hu Li   +7 more
wiley   +1 more source

Drug Safety Assessment Based on Target Affinity, Drug Exposure and Plasma Protein Binding: Drug-Induced Cardiotoxicity from a Translational Pharmacology Perspective. [PDF]

Int J Mol Sci
Catozzi S, Sips F, Totis N, Bisotti MA, Stathopoulos S, Torchia M, Emili L, Carbone V, Baker C, Mahoney JM, Röshammar D, Cardioverse Project Team.   +11 more
europepmc   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

DrugForm-TAS: Target-Agnostic Selectivity as Proteome-wide Binding Propensity Estimation. [PDF]

Comput Struct Biotechnol J
Tashchilova A, Khokhlov I, Seikin A, Bugaev-Makarovskiy N, Glushkova O, Yudin V, Keskinov A, Yudin S, Svetlichnyy D, Skvortsova V.   +9 more
europepmc   +1 more source

A multi-target drug design method based on target feature fusion. [PDF]

BMC Bioinformatics
Liu H, Lin X, Hu J, Zhang X.
europepmc   +1 more source

Biophysical Sensing Tools in Drug Discovery: Integrating Kinetics, Thermodynamics, Cellular Target Engagement and Structure. [PDF]

Sensors (Basel)
Balıkçı E, Akıl C.
europepmc   +1 more source

Advancing Drug Discovery with AI: Machine and Deep Learning Strategies for Target Identification and Precision Nanomedicine. [PDF]

Int J Nanomedicine
Chakraborty A, Gholap AD, Khuspe PR, Sundaram G, Webster TJ, Khalid M, Haris MS, Faiyazuddin M.   +7 more
europepmc   +1 more source

GraphDTA for predicting drug–target binding affinity

openaire   +1 more source

Investigation of metformin analogues in targeting signaling molecules of head and neck cancer pathways by computational approaches. [PDF]

Sci Rep
Arora P, Kollur SP, Shanthappa PM, Yadav B, Tenguria M, Rai N, Upadhye VJ, Singh P.   +7 more
europepmc   +1 more source