Results 121 to 130 of about 2,729,950 (336)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Membrane penetration and trapping of an active particle [PDF]

, 2019
The interaction between nano- or micro-sized particles and cell membranes is of crucial importance in many biological and biomedical applications such as drug and gene delivery to cells and tissues.
Daddi-Moussa-Ider, Abdallah, Goh, Segun, Guzmán-Lastra, Francisca, Hoell, Christian, Liebchen, Benno, Löwen, Hartmut, Mathijssen, Arnold J. T. M., Menzel, Andreas M., Scholz, Christian   +8 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Predicting drug and target interaction with dilated reparameterize convolution

Scientific Reports
Predicting drug-target interaction (DTI) stands as a pivotal and formidable challenge in pharmaceutical research. Many existing deep learning methods only learn the high-dimensional representation of ligands and targets on a small scale.
Moping Deng, Jian Wang, Yiming Zhao, Yongjia Zhao, Hao Cao, Zhuo Wang   +5 more
doaj   +1 more source

Leveraging Image-Derived Phenotypic Measurements for Drug-Target Interaction Predictions

Cancer Informatics, 2019
In recent years, protein kinases have become some of the most significant drug targets in cancer patients. Kinases are known to regulate the activity of many human proteins, and consequently their inhibition has been used to control cancer proliferation.
Srikanth Kuthuru, Adam T Szafran, Fabio Stossi, Michael A Mancini, Arvind Rao   +4 more
doaj   +1 more source

Kernel methods for in silico chemogenomics

, 2007
Predicting interactions between small molecules and proteins is a crucial ingredient of the drug discovery process. In particular, accurate predictive models are increasingly used to preselect potential lead compounds from large molecule databases, or to
Jacob, Laurent, Vert, Jean-Philippe
core   +1 more source

Link Mining for Kernel-based Compound-Protein Interaction Predictions Using a Chemogenomics Approach

, 2017
Virtual screening (VS) is widely used during computational drug discovery to reduce costs. Chemogenomics-based virtual screening (CGBVS) can be used to predict new compound-protein interactions (CPIs) from known CPI network data using several methods ...
A Lavecchia, ACA Nascimento, C-C Chang, D Rogers, H Ding, L Jacob, M Bouchard, M Gonen, M Hattori, MN Drwal, S Daminelli, T Laarhoven van, T Laarhoven van, TF Smith, Y Liu, Y Yamanishi   +15 more
core   +1 more source

Influenza A nucleoprotein binding sites for antivirals: current research and future potential [PDF]

, 2014
This document is the Accepted Manuscript version of the following article: Andreas Kukol and Hershna Patel, ‘Influenza A nucleoprotein binding sites for antivirals: current research and future potential’, Future Biology, Vol 9(7): 625-627, July 2014. The
Kukol, A, Kukol, A, Patel, H., Patel, H.
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source