Results 101 to 110 of about 5,671,792 (258)
Social issues in Australia, 1985
, 2019 The main purpose of the survey was to obtain benchmark data on attitudes to drugs which would assist those involved in the National Campaign Against Drug Abuse Series to prepare and monitor a media campaign.
National Drug Education Committee
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Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns
Journal of the Brazilian Chemical Society, 2003 We have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various ...
Makino Shingo +2 more
doaj
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Lynn Ruane: Drug courts are not the solution to Ireland's drug problem.
, 2019 We cannot have a National Drug Strategy that prefers the drug court to a health-focused approach.....
Ruane, Lynn
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National Campaign Against Drug Abuse Social Issues Survey, 1991
, 2018 This study is the third in a series of national household surveys to examine current attitudes towards drugs and drug problems, usage of drugs, and to assess changes in these attitudes and usage over the period 1985-1991.
Department of Health, Housing and Community Services
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Phoenix, Arizona: Profile of Drug Indicators
This title contains one or more publications. Other or earlier statewide and local profiles for states available from White House office webpage http://www.whitehousedrugpolicy.gov/statelocal/state_and_city_profiles.html or ASI non-depository collection
United States Office of National Drug Control Policy
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