Results 141 to 150 of about 5,671,792 (258)

A Quantitative Analysis of Street-Level Drugs Seized in New South Wales, Australia: Purity, Dose and Adulterants. [PDF]

Drug Alcohol Rev
Smith JL, Harvey CA, NSW Police Force, Ewers CJ, Seyfang KE, Bottero ED, Brown JA, Jiranantakan T.   +7 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Citalopram: suspected drug interaction with cocaine; prescribers should consider enquiring about illicit drug use.

, 2016
The UK Medicines and Healthcare products Regulatory Agency received a Coroner’s report that raised concerns about a suspected drug interaction between citalopram and cocaine after the death of a man due to subarachnoid haemorrhage.

core  

Reducing Antibiotic Drug Use Effects on Clostridioides difficile Colonization in Nursing Home Residents¹. [PDF]

Emerg Infect Dis
Reeves M, Mangalea MR, Gowler CD, Paul P, Wolford H, Lutgring JD, Reddy SC, Halpin AL, McDonald LC, Slayton RB.   +9 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Call for drug testing labs following party drug death.

, 2016
A conference in Dublin has heard about the success of the labs in Wales - which allow drug users test their drugs for potentially lethal ingredients.

core  

Reductions in Advanced Chronic Liver Disease Among People Who Inject Drugs: The ETHOS Engage Study. [PDF]

Liver Int
Conway A, Valerio H, Payne J, Silk D, Marshall AD, Martinello M, Tillakeratne S, Dharmayani PNA, Milat A, Amin J, Read P, Degenhardt L, Stevens A, Hayllar J, Christmass M, Cock V, Doumany J, Grebely J, Dore GJ, ETHOS Engage Study Group.   +19 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Recent progress in cancer multidrug resistance and therapeutic options associated with protein damage response. [PDF]

Protein Cell
Shao F, Tang D, Li L, Xu X, Deng CX.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source