Results 201 to 210 of about 12,292,416 (404)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Drug-Related Engrams and Their Role in the Persistence and Recurrence of Drug-Related Behaviors. [PDF]

Hippocampus
Cutler M, Thati A, Grella SL.
europepmc   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

PS3N: leveraging protein sequence-structure similarity for novel drug-drug interaction discovery. [PDF]

Sci Rep
Islam S, Abbasi A, Agarwal N, Zheng W, Doretto G, Adjeroh DA.   +5 more
europepmc   +1 more source

Observations on the Reactions of the Larvae of Ancylostoma canium and Ancylostoma braziliense to Various Drugs and Chemical Compounds Based on In Vitro Tests

, 1953
EARL B. RITCHIE, William C. King
openalex   +1 more source

THE SPREAD OP DRUGS USED FOR SPINAL ANESTHESIA [PDF]

, 1956
Tetsuo Kitahara, Shinnosuke Kuri, Jun Yoshida   +2 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Editorial

Drug Analytical Research, 2022
Drug Analytical Research
doaj  

Models attempting to quantify the relationship between drug development and financial return are missing a key element: the effect on post-approval research. [PDF]

Health Aff Sch
Crippen D, Axelsen K.
europepmc   +1 more source

On the capillary circulation of the blood in the suprarenal body of mice under physiological conditions and the influence of drugs¹ [PDF]

, 1935
Torgny Sjöstrand
openalex   +1 more source