Results 261 to 270 of about 8,662,910 (358)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

A primer on prescription drug pricing benchmarks in the United States. [PDF]

J Manag Care Spec Pharm
Hung A, Dickson S.
europepmc   +1 more source

Rapid duplexed detection of illicit drugs in wastewater using gold nanoparticle conjugated aptamer sensors

, 2019
Kang Mao, Jun Ma, Xiqing Li, Zhugen Yang
openalex   +2 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Harnessing Single-Cell RNA-Seq for Computational Drug Repurposing in Cancer Immunotherapy. [PDF]

Pharmaceuticals (Basel)
Cheng OJ, Tran TTT, Chen YA, Tan AC.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Addressing infectious diseases in Africa by accelerating drug discovery through data science. [PDF]

Commun Med (Lond)
Turon G, Hlozek J, Duran-Frigola M, Chibale K, Woodland JG.   +4 more
europepmc   +1 more source

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

, 2019
James B. Murray, James Davidson, I‐Jen Chen, Ben Davis, P. Dokurno, Christopher J Graham, Richard Harris, Allan M. Jordan, Natalia Matassova, C. Pedder, Stuart Ray, Stephen D. Roughley, Julia Smith, C. Walmsley, Yikang Wang, N.E. Whitehead, D.S. Williamson, Patrick Casara, Thierry Le Diguarher, John A. Hickman, Jerome Stark, András Kotschy, Olivier Geneste, Roderick E. Hubbard   +23 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source