Results 21 to 30 of about 7,686,929 (306)
Synergistic drug combinations from electronic health records and gene expression. [PDF]
, 2016 ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William +19 more
core +2 more sources
Cardiovascular Therapeutics, 2009 Understanding and documentation of drug–drug interactions (DDIs) are an important component of drug development, and of clinical therapeutics. Because clinical DDI studies are costly, time‐consuming, and involve some risk, not all clinical DDI questions can be realistically addressed through human DDI trials.In vitromodels have been used to identify ...
openaire +2 more sources
DARU Journal of Pharmaceutical Sciences, 2012 Editorial Active pharmaceutical ingredients (APIs) are most conveniently developed and delivered orally as solid dosage forms that contain a defined crystalline form of an API. Co-crystal is a crystalline entity formed by two different or more molecular entities where the intermolecular interactions are weak forces like hydrogen bonding and π-π ...
openaire +2 more sources
Jornal Brasileiro de Nefrologia, 2014 A doenca renal cronica (DRC), considerada a grande epidemia deste milenio, tem prevalencia media de 11% nos paises desenvolvidos. Infelizmente, no Brasil ainda nao dispomos de dados definitivos sobre a prevalencia da DRC, contudo, estudo realizado em amostra de 24.248 individuos adultos, utilizando o criterio de DRC baseado em duas determinacoes da ...
openaire +2 more sources
Recent updates on incubation of drug craving: a mini-review [PDF]
, 2015 Cue-induced drug craving progressively increases after prolonged withdrawal from drug self-administration in laboratory animals, a behavioral phenomenon termed 'incubation of drug craving.' Studies over the years have revealed several important neural ...
Abdolahi +39 more
core +1 more source
Mechanisms of burst release from pH-responsive polymeric microparticles. [PDF]
, 2011 Microencapsulation of drugs into preformed polymers is commonly achieved through solvent evaporation techniques or spray drying. We compared these encapsulation methods in terms of controlled drug release properties of the prepared microparticles and ...
Donaldson, M +4 more
core +1 more source
The Drug Problem and Organized Crime, Illicit Financial Flows, Corruption and Terrorism [PDF]
, 2017 An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...
core +1 more source
Communication and Language Profiles of Children Treated for Posterior Fossa Brain Tumors
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Cognitive and language deficits are frequently reported sequelae of posterior fossa brain tumors (PFBT). Typically, delayed onset impedes prompt assessment and early intervention. This has devastating implications for quality of life.
Zara Sved +4 more
wiley +1 more source
Drug-drug interactions in repeat prescriptions at village dispensaries (bereg) in Malta [PDF]
, 2013 Inappropriate treatments and drug-drug interactions (DDIs) are known to occur in settings where repeat prescriptions are issued. In view of this, a study was carried out to document any such problematic drug prescribing and propose changes that would
Bugeja, Anton
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The HIT network was established in 2000 to create a population‐based structure aiming to improve survival rates and reduce late effects for children with central nervous system (CNS) tumors by conducting comprehensive clinical trials.
Stefan Rutkowski +59 more
wiley +1 more source