Results 41 to 50 of about 10,901,451 (408)

Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation

mBio, 2020
New antimalarial drugs are needed. The benzoxaborole AN13762 showed excellent activity against cultured Plasmodium falciparum, against fresh Ugandan P. falciparum isolates, and in murine malaria models.
Kirthana M. V. Sindhe, Wesley Wu, Jenny Legac, Yong-Kang Zhang, Eric E. Easom, Roland A. Cooper, Jacob J. Plattner, Yvonne R. Freund, Joseph L. DeRisi, Philip J. Rosenthal   +9 more
doaj   +1 more source

The three-dimension preclinical models for ferroptosis monitoring

Frontiers in Bioengineering and Biotechnology, 2022
As a new programmed cell death process, ferroptosis has shown great potential and uniqueness in experimental and treatment-resistant cancer models. Currently, the main tools for drug research targeting ferroptosis are tumor cells cultured in vitro and ...
Yiming Meng, Jing Sun, Guirong Zhang, Tao Yu, Haozhe Piao, Haozhe Piao   +5 more
doaj   +1 more source

Multi-View Substructure Learning for Drug-Drug Interaction Prediction [PDF]

arXiv, 2022
Drug-drug interaction (DDI) prediction provides a drug combination strategy for systemically effective treatment. Previous studies usually model drug information constrained on a single view such as the drug itself, leading to incomplete and noisy information, which limits the accuracy of DDI prediction.
arxiv  

DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity. [PDF]

, 2018
An individual malignant tumor is composed of a heterogeneous collection of single cells with distinct molecular and phenotypic features, a phenomenon termed intratumoral heterogeneity.
Anchang, Benedict, Bendall, Sean C, Davis, Kara L, Fienberg, Harris G, Karacosta, Loukia G, Nolan, Garry P, Plevritis, Sylvia K, Tibshirani, Robert, Williamson, Brian D   +8 more
core   +1 more source

Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma

Frontiers in Immunology, 2022
BackgroundThe coronavirus disease (COVID-19) pandemic has posed a significant challenge for global health systems. Increasing evidence shows that asthma phenotypes and comorbidities are major risk factors for COVID-19 symptom severity.
Hongwei Fang, Hongwei Fang, Zhun Sun, Zhouyi Chen, Anning Chen, Donglin Sun, Yan Kong, Hao Fang, Hao Fang, Guojun Qian   +9 more
doaj   +1 more source

Recent updates on incubation of drug craving: a mini-review [PDF]

, 2015
Cue-induced drug craving progressively increases after prolonged withdrawal from drug self-administration in laboratory animals, a behavioral phenomenon termed 'incubation of drug craving.' Studies over the years have revealed several important neural ...
Abdolahi, Bedi, Bienkowski, Chauvet, Chauvet, Conrad, Counotte, Fanous, Gawin, Grimm, Grimm, Guillem, Halbout, Hollander, Koya, Krasnova, Lee, Li, Li, Li, Loweth, Lu, Lu, Lu, Ma, Marchant, Neisewander, Pickens, Purgianto, Shalev, Shepard, Solinas, Sorge, Theberge, Thiel, Thiel, Tran-Nguyen, Uejima, Wang, Xi   +39 more
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Detecting drug-drug interactions using artificial neural networks and classic graph similarity measures [PDF]

, 2019
Drug-drug interactions are preventable causes of medical injuries and often result in doctor and emergency room visits. Computational techniques can be used to predict potential drug-drug interactions. We approach the drug-drug interaction prediction problem as a link prediction problem and present two novel methods for drug-drug interaction prediction
arxiv   +1 more source

Drug-drug interactions in repeat prescriptions at village dispensaries (bereg) in Malta [PDF]

, 2013
Inappropriate treatments and drug-drug interactions (DDIs) are known to occur in settings where repeat prescriptions are issued. In view of this, a study was carried out to document any such problematic drug prescribing and propose changes that would
Bugeja, Anton
core  

Antimicrobials in animal agriculture: Parables and policy [PDF]

, 2015
In addition to the scientific, economic, regulatory and other policy factors that impact on antimicrobial decision-making in different jurisdictions around the world, there exist ethical, social and cultural bases for the contemporary use of these ...
Aarestrup, Aarestrup, Aarestrup, Aarestrup, Alali, Amachawadi, Bunner, Cavaco, Checkland, Cottell, Dean, Doyle, Dutil, Food and Drug Administration, Food and Drug Administration, Food and Drug Administration, Food and Drug Administration, G. H. Loneragan, G. Midgley, H. M. Scott, H. Morgan Scott, Hollway, Hurd, Hurd, Jaap A. Wagenaar, Jan, Jan, Kanwar, Kanwar, Keelara, Lowrance, Maturana, McIntosh, Midgley, Midgley, Midgley, Midgley, Platt, Popper, Ulrich, Von Foerster, Von Glasersfeld, World Health Organization, World Health Organization   +43 more
core   +1 more source