Results 41 to 50 of about 12,292,416 (404)
Current Concepts on Drug Abuse and Dependence [PDF]
, 2015 Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about ...
Baconi, Daniela Luiza +5 more
core +3 more sources
Jornal Brasileiro de Nefrologia, 2014 A doenca renal cronica (DRC), considerada a grande epidemia deste milenio, tem prevalencia media de 11% nos paises desenvolvidos. Infelizmente, no Brasil ainda nao dispomos de dados definitivos sobre a prevalencia da DRC, contudo, estudo realizado em amostra de 24.248 individuos adultos, utilizando o criterio de DRC baseado em duas determinacoes da ...
openaire +3 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The Unfolded Protein Response and Autophagy as Drug Targets in Neuropsychiatric Disorders
Frontiers in Cellular Neuroscience, 2020 Neurons are polarized in structure with a cytoplasmic compartment extending into dendrites and a long axon that terminates at the synapse. The high level of compartmentalization imposes specific challenges for protein quality control in neurons making ...
Vignesh Srinivasan +5 more
doaj +1 more source
Cardiovascular Therapeutics, 2009 Understanding and documentation of drug–drug interactions (DDIs) are an important component of drug development, and of clinical therapeutics. Because clinical DDI studies are costly, time‐consuming, and involve some risk, not all clinical DDI questions can be realistically addressed through human DDI trials.In vitromodels have been used to identify ...
openaire +3 more sources
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Strategy for applying utility model patents in clinical nursing (临床护理用具实用新型专利申请心得体会)
中西医结合护理, 2021 This paper summarized the strategy for applying utility model patents in clinical nursing. Issues about meaning of patent, application procedure and design inspiration were discussed and shared, in order to provide reference in design and application of ...
QIAO Shouang (乔首昂) +2 more
doaj +1 more source
Arrests for Drug Offenses in Alaska: 2000-2011 [PDF]
, 2013 This fact sheet presents data on arrests for drug offenses made by Alaska police agencies for the period 2000 through 2011. The report presents drug offense arrest information for both adults and juveniles for the 12-year period, including number of drug
Myrstol, Brad A.
core
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
HNCDB: An Integrated Gene and Drug Database for Head and Neck Cancer
Frontiers in Oncology, 2019 Head and neck cancer (HNC) is the sixth most common cancer worldwide. Over the last decade, an enormous amount of well-annotated gene and drug data has accumulated for HNC. However, a comprehensive repository is not yet available.
Qingbin Zhang +8 more
doaj +1 more source