Drug Absorption Studies: In Situ, In Vitro and In Silico Models [PDF]
, 2022 This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug ...
C. Ehrhardt, Kwang-Jin Kim
core +2 more sources
Prediction of nasal spray drug absorption influenced by mucociliary clearance. [PDF]
PLoS One, 2021 Evaluation of nasal spray drug absorption has been challenging because deposited particles are consistently transported away by mucociliary clearance during diffusing through the mucus layer.
Shang Y +5 more
europepmc +2 more sources
Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability. [PDF]
Pharmaceutics, 2021 P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor intestinal permeation and limited bioavailability following oral administration.
Nguyen TT, Duong VA, Maeng HJ.
europepmc +2 more sources
Potential Applications of Chitosan-Based Nanomaterials to Surpass the Gastrointestinal Physiological Obstacles and Enhance the Intestinal Drug Absorption. [PDF]
Pharmaceutics, 2021 The small intestine provides the major site for the absorption of numerous orally administered drugs. However, before reaching to the systemic circulation to exert beneficial pharmacological activities, the oral drug delivery is hindered by poor ...
Pathomthongtaweechai N, Muanprasat C.
europepmc +2 more sources
Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics. [PDF]
Br J Pharmacol, 2020 The importance of drug dosing time in pharmacokinetics, pharmacodynamics, and toxicity is receiving increasing attention from the scientific community.
Bicker J, Alves G, Falcão A, Fortuna A.
europepmc +2 more sources
Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions. [PDF]
Drug Metab Dispos, 2020 The organic anion transporting polypeptide (OATP)2B1 is localized on the basolateral membrane of hepatocytes and is expressed in enterocytes. Based on its distribution pattern and functional similarity to OATP1B-type transporters, OATP2B1 might have a ...
Chen M +6 more
europepmc +2 more sources
Food Effects on Oral Drug Absorption: Application of Physiologically-Based Pharmacokinetic Modeling as a Predictive Tool. [PDF]
Pharmaceutics, 2020 The bioavailability of an orally administered small molecule is often dictated by drug-specific physicochemical characteristics and is influenced by many biological processes.
Cheng L, Wong H.
europepmc +2 more sources
Counterion Effects on Nano-confined Metal-Drug-DNA Complexes [PDF]
Beilstein J. Nanotechnol. 2016 vol 7 page 62 - 67, 2014 We have explored morphology of DNA molecules bound with Cu-complexes of piroxicam molecules, a non-steroidal anti-inflammatory drug (NSAID), under one-dimensional confinement of thin films and have studied the effect of counterions present in a buffer.
Bera, Mrinal K. +6 more
arxiv +4 more sources
Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches. [PDF]
Pharmaceutics, 2019 The main objective of this review is to discuss recent advancements in the overall investigation and in vivo prediction of drug absorption. The intestinal permeability of an orally administered drug (given the value Peff) has been widely used to ...
Dahlgren D, Lennernäs H.
europepmc +2 more sources
Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes. [PDF]
Pharmaceutics, 2019 New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are being developed every year, making it vital to find a non-invasive route such as nasal or pulmonary for their administration.
Ghadiri M, Young PM, Traini D.
europepmc +2 more sources