Results 1 to 10 of about 750,762 (351)

A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption [PDF]

, 2012
Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo ...
Adibkia, Khosro, Barzegar-Jalali, Azim, Barzegar-Jalali, Mohammad, Mohammadi, Ghobad, Mohammadi, Kaivan, Nokhodchi, Ali, Valizadeh, Hadi   +6 more
core   +4 more sources

A two-phase two-layer model for transdermal drug delivery and percutaneous absorption [PDF]

, 2014
One of the promising frontiers of bioengineering is the controlled release of a therapeuticdrug from a vehicle across the skin (transdermal drug delivery).
de Monte, Filippo, Pontrelli, Giuseppe
core   +2 more sources

Evaluating the Impact of Intestinal Bile Salts on Drug Absorption Using PBPK Modeling: Case Studies With Efavirenz, Cinnarizine, and Posaconazole [PDF]

CPT: Pharmacometrics & Systems Pharmacology
A high number of poorly soluble compounds are being developed; thus, understanding the factors that influence their absorption is critical. Intestinal bile salts, which facilitate micelle‐mediated solubilization, are particularly important for drugs with
Laura G. Al‐Amiry Santos, Sebastian Polak, Karen Rowland Yeo   +2 more
doaj   +2 more sources

Surge Dose^® Formulations of NSAIDs Provide for Ultra-Rapid and Consistent Drug Absorption in Both the Fasted and Fed State as Predicted by Physiologically Based Biopharmaceutics Modelling [PDF]

Pharmaceutics
Background/Objectives: This paper describes the use of physiologically based biopharmaceutics modelling (PBBM) to predict the effect of food on diclofenac and ibuprofen absorption from ultra-rapid-release Surge Dose® tablets.
Harri Dickinson, Zhixin Jiang, Paul A. Dickinson, Ian R. Wilding, Geraldine A. Elliott   +4 more
doaj   +2 more sources

Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets

Haematologica, 2022
The multidrug resistance protein 4 (MRP4) is highly expressed in platelets and several lines of evidence point to an impact on platelet function. MRP4 represents a transporter for cyclic nucleotides as well as for certain lipid mediators. The aim of the
Robert Wolf, Sophie Grammbauer, Raghavendra Palankar, Céline Tolksdorf, Eileen Moritz, Andreas Böhm, Mahmoud Hasan, Annika Hafkemeyer, Andreas Greinacher, Mladen V. Tzvetkov, Bernhard H. Rauch, Gabriele Jedlitschky   +11 more
doaj   +1 more source

Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics

Pharmaceutics, 2023
Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary tracer ...
Theodora Tzakri, Lara Rehenbrock, Stefan Senekowitsch, Adrian Rump, Philipp Schick, Julius Krause, Marie-Luise Kromrey, Michael Grimm, Werner Weitschies   +8 more
doaj   +1 more source

Gene Expression and Protein Abundance of Nuclear Receptors in Human Intestine and Liver: A New Application for Mass Spectrometry-Based Targeted Proteomics

Molecules, 2022
Background: Unwanted drug-drug interactions (DDIs), as caused by the upregulation of clinically relevant drug metabolizing enzymes and transporter proteins in intestine and liver, have the potential to threaten the therapeutic efficacy and safety of ...
Christoph Wenzel, Lisa Gödtke, Anne Reichstein, Markus Keiser, Diana Busch, Marek Drozdzik, Stefan Oswald   +6 more
doaj   +1 more source

An Advanced Bioreactor Simulating Dynamic Physiological Conditions in the Human Ascending Colon: MimiCol³

Pharmaceutics, 2022
In recent years, the colon has become a hot topic in biopharmaceutical research as several in vitro models of the human colon have been presented. A major focus is on the characterization of the microbiota and its capabilities.
Regine Beeck, Annemarie Dols, Felix Schneider, Dariah-Sohreh Seradj, Julius Krause, Philipp Schick, Werner Weitschies   +6 more
doaj   +1 more source

Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine

Pharmaceutics, 2023
Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs.
Stefan Senekowitsch, Constantin Foja, Toni Wildgrube, Philipp Schick, Christoph Rosenbaum, Julius Krause, Friederike Brokmann, Marie-Luise Kromrey, Stefan Engeli, Werner Weitschies, Michael Grimm   +10 more
doaj   +1 more source

Influence of Different Diets on the Degradation of Sulfasalazine by Colon Bacteria Determined Using MimiCol³

Pharmaceuticals, 2023
The microbiome of the colon is characterized by its great diversity. This varies not only intra- but also interindividually and is influenced by endogenous and exogenous factors, such as dietary and lifestyle factors.
Dariah-Sohreh Seradj, Regine Beeck, Annika Haase, Julius Krause, Philipp Schick, Werner Weitschies   +5 more
doaj   +1 more source