Results 141 to 150 of about 5,685,542 (420)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Application of Rat In Situ Single-pass Intestinal Perfusion in the Evaluation of Presystemic Extraction of Indinavir Under Different Perfusion Rates

Journal of the Formosan Medical Association, 2008
First-pass effect has been an important concern for oral pharmaceuticals. An in vivo system was developed for measuring different concentrations of pharmaceuticals in the portal vein and hepatic vein (via the inferior vena cava) for delineating ...
Yunn-Fang Ho, Ming-Yen Lai, Hsiu-Ying Yu, Da-Kong Huang, Wei-Cherng Hsueh, Tung-Hu Tsai, Chia-Chun Lin   +6 more
doaj   +1 more source

Enhanced Intestinal Absorption of Insulin by Capryol 90, a Novel Absorption Enhancer in Rats: Implications in Oral Insulin Delivery

Pharmaceutics, 2020
Labrasol® is a self-emulsifying excipient that contains saturated polyglycolysed C6–C14 glycerides and this additive is known to improve the intestinal absorption of poorly absorbed drugs after oral administration.
Hiroki Ukai, Kazuki Iwasa, Takamasa Deguchi, Masaki Morishita, Hidemasa Katsumi, Akira Yamamoto   +5 more
doaj   +1 more source

A comparison of drug transport in pulmonary absorption models: isolated perfused rat lungs, respiratory epithelial cell lines and primary cell culture [PDF]

, 2017
Purpose: To evaluate the ability of human airway epithelial cell layers and a simple rat isolated perfused lung (IPL) model to predict pulmonary drug absorption in rats in vivo. Method: The permeability of seven compounds selected to possess a range
A Avdeef, A Tronde, A Tronde, A Tronde, B Forbes, B Forbes, B Forbes, B Forbes, B Forbes, Ben Forbes, C Ehrhardt, C Ehrhardt, CD Edwards, CI Grainger, CJ Morris, Cynthia Bosquillon, E Bogaard van den, F Manford, FJC Bayard, G Borchard, G Horvath, H Lin, HX Ong, JE Hastedt, KA Foster, KJ Kim, Linda Fredlund, M Beck-Broichsitter, M Beck-Broichsitter, M Madlova, M Sakagami, Michaela Madlova, Nicola Clear, Nilesh Patel, NR Mathias, NR Matthias, P Bäckman, P Gerde, RM Jones, SJ Enna, SP Collingwood, T Mainprize, T Morita   +42 more
core   +3 more sources

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Gastric emptying and drug absorption [PDF]

, 1982
SIGLEAvailable from British Library Document Supply Centre- DSC:D43939/82 / BLDSC - British Library Document Supply CentreGBUnited ...
Nimmo, W. S.
core  

Pharmacokinetics of dexamethasone in broiler chickens [PDF]

, 2012
Dexamethasone (DEX) is a synthetic derivate of cortisol and is one of the most potent glucocorticoids in man and animal. It is well known as an anti-inflammatory drug in many species. In poultry, however, data on the use of DEX are scarce.
Croubels, Siska, De Backer, Patrick, De Baere, Siegrid, Plessers, Elke, Watteyn, Anneleen, Wyns, Heidi   +5 more
core   +1 more source

Physicochemical and physiological mechanisms for the effects of food on drug absorption: The role of lipids and pH [PDF]

, 1997
Drugs are absorbed after oral administration as a consequence of a complex array of interactions between the drug, its formulation, and the gastrointestinal (GI) tract.
Charman, William N., Dressman, Jennifer B., Mithani, Sabena, Porter, Christopher J. H.   +3 more
core   +1 more source

Development of a drug delivering round window niche implant for cochlear pharmacotherapy

Drug Delivery
Background There exists an unfulfilled requirement for effective cochlear pharmacotherapy. Controlled local drug delivery could lead to effective bioavailability. The round window niche (RWN), a cavity in the middle ear, is connected to the cochlea via a
Chunjiang Wei, Ziwen Gao, Martina Knabel, Martin Ulbricht, Stefan Senekowitsch, Peter Erfurt, Norman Maggi, Bastian Zwick, Thomas Eickner, Farnaz Matin-Mann, Anne Seidlitz, Thomas Lenarz, Verena Scheper   +12 more
doaj   +1 more source

Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin [PDF]

, 2012
A four compartment mechanistic mathematical model is developed for the pharmacokinetics of the commonly used anti-malarial drug artesunate and its principle metabolite dihydroartemisinin following oral administration of artesunate.
Adam J. Hall, Banks, Batty, Bergstrand, Cheng, Cheung, Cole, Godfrey, Gordi, Jacquez, John A.D. Aston, Joy, Karunajeewa, Klonis, LaCrue, Li, Li, Lindegardh, Lindegårdh, Meshnick, Michael J. Chappell, Morris, Newton, O’Neill, Rössler, Saralamba, Scholar, Seber, Starčević, Stephen A. Ward, Tan, Van Agtmael, Varma, White, WHO, WHO, Woerdenbag   +36 more
core   +2 more sources