SR 2D micro-XRF imaging on entire rat thin sections in view of a pharmacokinetic study of a new bromine containing drug agains tuberculosis [PDF]
, 2011 Tuberculosis (TB) is a common and often deadly infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis in humans. Because of population growth, the absolute number of new cases is still increasing.
Appel, Karen +7 more
core +1 more source
Natural treasures from Picrorhiza kurrooa: a computational exploration of drug-like properties and bioactivity of kutkin, cucurbitacin, apocynin and lupanine [PDF]
Background: To analyse and predict the basic pharmacokinetic and toxicological properties of four compounds of interest found in Picrorhiza kurroa (Kutkin, cucurbitacin, apocynin and lupanine) using computational bioinformatics tools.
Britto, G. Francis +2 more
core +2 more sources
CMINNs: Compartment Model Informed Neural Networks -- Unlocking Drug Dynamics [PDF]
arXivIn the field of pharmacokinetics and pharmacodynamics (PKPD) modeling, which plays a pivotal role in the drug development process, traditional models frequently encounter difficulties in fully encapsulating the complexities of drug absorption, distribution, and their impact on targets.
arxiv
THE ABSORPTION AND ELIMINATION OF SOME COMMONLY USED DRUGS,WITH PRACTICAL DEDUCTIONS FROM A KNOWLEDGE OF THE SAME. [PDF]
, 1907 E. R. Zemp
openalex +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose To compare plan quality among photon volumetric modulated arc therapy (VMAT) and intensity‐modulated proton therapy (IMPT) with robustness using three different proton beam delivery systems with various spot size (σ) ranges: cyclotron‐generated proton beams (CPBs) (σ: 2.7–7.0 mm), linear accelerator proton beams (LPBs) (σ: 2.9–5.5 mm),
Tara Gray +9 more
wiley +1 more source
On the Stereoselective Pharmacokinetics of Eflornithine and Prediction of Drug Tissue to Plasma Concentration Ratios [PDF]
, 2009 Eflornithine is one of two registered drugs for the treatment of late-stage human African trypanosomiasis, a uniformly fatal neglected disease with sixty million people are at risk of being infected.
Jansson Löfmark, Rasmus
core
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose Quantify the impact of additional imaging doses on clinical dose constraints during lung stereotactic body radiotherapy (SBRT) treatment utilizing stereoscopic/monoscopic real‐time tumor monitoring. Materials and Methods Thirty lung SBRT patients treated with the volumetric arc therapy technique were randomly selected from the ...
Ruwan Abeywardhana, Mike Sattarivand
wiley +1 more source
Drug Absorption Efficiency in Caenorhbditis elegans Delivered by Different Methods
PLoS ONE, 2013 Background Caenorhbditis elegans has being vigorously used as a model organism in many research fields and often accompanied by administrating with various drugs.
Shan-Qing Zheng +4 more
semanticscholar +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract This study aimed to evaluate the dose‐exposure reduction effect of a crystalline lens with a bismuth eye shield using cone‐beam computed tomography (CBCT) for head image‐guided radiation therapy. The ocular surface dose of the head phantom (THRA‐1) is defined as a crystalline lens exposure dose and is measured using a radiophotoluminescence ...
Tatsuya Yoshida +5 more
wiley +1 more source
Modeling and administration scheduling of fractional-order pharmacokinetic systems [PDF]
arXiv, 2017 Fractional-order dynamical systems were recently introduced in the field of pharmacokinetics where they proved powerful tools for modeling the absorption, disposition, distribution and excretion of drugs which are liable to anomalous diffusion, deep tissue trapping and other nonlinear phenomena.
arxiv