Impact of Transporter Polymorphisms on Drug Development: Is It Clinically Significant? [PDF]
, 2016 Drug transporters are becoming increasingly recognized as relevant to the drug development process. This may be a reflection of increasing target complexity and the need for high-affinity interaction with drug targets that minimize off-target side ...
Kim, Richard B. +2 more
core +1 more source
Impact of gastrointestinal physiology on drug absorption in special populations - An UNGAP review.
European Journal of Pharmaceutical Sciences, 2020 Cordula Stillhart +19 more
semanticscholar +1 more source
Measurement of CT radiation beam width with a pencil ionization chamber and radiopaque mask
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose This study compares fan beam CT scanner radiation beam widths measured with a pencil ionization chamber‐radiopaque mask technique with commonly used film and computed radiography (CR) measurements. Methods For a given fan beam CT scanner x‐ray beam, the ionization chamber‐mask technique determines the radiation beam width by exposing a
Rani Al‐Senan +2 more
wiley +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract The thermoluminescence dosimeter (TLD) sheet is a measurement device coated with manganese‐doped LiB3O5 in sheet form. The sheet is 0.2‐mm thick and flexible. Hence, it can fit and be installed on irregular surfaces. The current study aimed to evaluate the feasibility of measuring patient surface doses during radiation therapy using TLD sheets.
Yuya Miyasaka +8 more
wiley +1 more source
Oral Drug Absorption and Drug Disposition in Critically Ill Cardiac Patients. [PDF]
Pharmaceutics, 2023 Harnisch LO +10 more
europepmc +1 more source
In vitro systems for the assessment of drug release from topical formulations and trans-membrane permeation [PDF]
, 1989 Numerous experimental methods have been developed to investigate drug release from vehicles and the percutaneous absorption of topically applied chemicals.
Haigh, J M, Smith, E W
core +1 more source
Monte Carlo modeling of radiation dose from radiation therapy with superficial x‐rays
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Introduction Superficial x‐rays (50–100 kVp) are used for treating non‐melanoma skin cancer and intraoperative radiation therapy (IORT). At these energies, the photoelectric effect significantly increases absorbed dose to bone compared to soft tissue.
Reham Barghash +3 more
wiley +1 more source
Characterization of Porcine Gingiva for Drug Absorption. [PDF]
J Pharm Sci, 2023 Wanasathop A +4 more
europepmc +1 more source
Chemi-net: a graph convolutional network for accurate drug property prediction [PDF]
arXiv, 2018 Absorption, distribution, metabolism, and excretion (ADME) studies are critical for drug discovery. Conventionally, these tasks, together with other chemical property predictions, rely on domain-specific feature descriptors, or fingerprints. Following the recent success of neural networks, we developed Chemi-Net, a completely data-driven, domain ...
arxiv
Inter-subject variability in oral drug absorption [PDF]
, 2015 A low and highly variable bioavailability is often the main reason for the failure of the development of a drug intended for oral delivery. Focusing on absorption instead of bioavailability from oral administration enables the identification and ...
Rabbie, S
core