Results 11 to 20 of about 750,762 (351)

The EyeFlowCell: Development of a 3D-Printed Dissolution Test Setup for Intravitreal Dosage Forms

Pharmaceutics, 2021
An in vitro dissolution model, the so-called EyeFlowCell (EFC), was developed to test intravitreal dosage forms, simulating parameters such as the gel-like consistency of the vitreous body.
Tobias Auel, Linus Großmann, Lukas Schulig, Werner Weitschies, Anne Seidlitz   +4 more
doaj   +1 more source

3D-Printing of Drug-Eluting Implants: An Overview of the Current Developments Described in the Literature

Molecules, 2021
The usage of 3D-printing for drug-eluting implants combines the advantages of a targeted local drug therapy over longer periods of time at the precise location of the disease with a manufacturing technique that easily allows modifications of the implant ...
Vanessa Domsta, Anne Seidlitz
doaj   +1 more source

3D Printing of Mini Tablets for Pediatric Use

Pharmaceuticals, 2021
In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms.
Julius Krause, Laura Müller, Dorota Sarwinska, Anne Seidlitz, Malgorzata Sznitowska, Werner Weitschies   +5 more
doaj   +1 more source

An In Vitro Model to Investigate the Potential of Solid Dispersions to Form Pharmacobezoars

Pharmaceutics, 2022
The formation of pharmacobezoars from suspensions of spray-dried amorphous solid dispersions (SD-ASDs) of new chemical entities (NCEs) and hydroxypropyl methylcellulose acetate succinate (HPMC-AS) represents a non-compound related adverse effect in ...
Hannes Gierke, Kerstin Schaefer, Lukas Gerlich, Ann-Cathrin Willmann, Verena Bialetzki, Georg Boeck, Teresa Pfrommer, Thomas Nolte, Werner Weitschies   +8 more
doaj   +1 more source

The use of heat and chemical penetration enhancers to increase the follicular delivery of erythromycin to the skin [PDF]

, 2019
Copyright © 2019. Published by Elsevier B.V.The effect of heat on the follicular absorption of drugs into the skin has not previously been investigated.
Akomeah, Alberti, Baden, Butcher, Cada, Coldman, Edwards, F. Caserta, FDA, Feldmann, Goh, Higuchi, ICH, Q2(R1), Kim, Kligman, Liu, M.B. Brown, McAuley, McAuley, Minson, Motwani, Motwani, OECD, Oliveira, Otberg, Park, Piazza, Pierard, Rancan, Saar, Santos, Sato, Shergill, Szabo, Teichmann, Toll, Twist, W.J. McAuley, Wood, Wood, Wood, Yarnitsky, Zhang   +42 more
core   +2 more sources

Prediction of the permeability of neutral drugs inferred from their solvation properties [PDF]

, 2015
Determination of drug absorption is an important component of the drug discovery and development process in that it plays a key role in the decision to promote drug candidates to clinical trials.
Milanetti, Edoardo, Raimondo, Domenico, Tramontano, Anna   +2 more
core   +1 more source

Evaluation of Pharmacobezoar Formation from Suspensions of Spray-Dried Amorphous Solid Dispersions: An MRI Study in Rats

Pharmaceutics, 2023
Spray-dried amorphous solid dispersions of new chemical entities and pH-dependent soluble polymer hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were found to form solid agglomerates in the gastrointestinal tract of rodents after oral ...
Hannes Gierke, Susan Mouchantat, Sabine Berg, Michael Grimm, Stefan Hadlich, Marie-Luise Kromrey, Thomas Nolte, Teresa Pfrommer, Vincent Rönnpagel, Adrian Rump, Kerstin Schaefer, Ann-Cathrin Willmann, Werner Weitschies   +12 more
doaj   +1 more source

Course of disease and risk factors for hospitalization in outpatients with a SARS-CoV-2 infection

Scientific Reports, 2022
We analyzed symptoms and comorbidities as predictors of hospitalization in 710 outpatients in North-East Germany with PCR-confirmed SARS-CoV-2 infection.
Eik Schäfer, Christian Scheer, Karen Saljé, Anja Fritz, Thomas Kohlmann, Nils-Olaf Hübner, Matthias Napp, Lizon Fiedler-Lacombe, Dana Stahl, Bernhard Rauch, Matthias Nauck, Uwe Völker, Stephan Felix, Guglielmo Lucchese, Agnes Flöel, Stefan Engeli, Wolfgang Hoffmann, Klaus Hahnenkamp, Mladen V. Tzvetkov   +18 more
doaj   +1 more source

Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research

Pharmaceutics, 2022
Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation.
Stefan Senekowitsch, Philipp Schick, Bertil Abrahamsson, Patrick Augustijns, Thomas Gießmann, Hans Lennernäs, Christophe Matthys, Luca Marciani, Xavier Pepin, Alan Perkins, Maximilian Feldmüller, Sarah Sulaiman, Werner Weitschies, Clive G. Wilson, Maura Corsetti, Mirko Koziolek   +15 more
doaj   +1 more source

Ex Vivo Visualization of Distribution of Intravitreal Injections in the Porcine Vitreous and Hydrogels Simulating the Vitreous

Pharmaceutics, 2023
The characterization of intravitreal dosage forms with regard to their behavior in vivo is usually explored in preclinical development through animal studies. In vitro vitreous substitutes (VS) to simulate the vitreous body for preclinical investigations
Tobias Auel, Lara Paula Scherke, Stefan Hadlich, Susan Mouchantat, Michael Grimm, Werner Weitschies, Anne Seidlitz   +6 more
doaj   +1 more source