Results 11 to 20 of about 5,685,542 (420)

Tetrafluoroethylene-Propylene Elastomer for Fabrication of Microfluidic Organs-on-Chips Resistant to Drug Absorption [PDF]

Micromachines, 2019
Organs-on-chips are microfluidic devices typically fabricated from polydimethylsiloxane (PDMS). Since PDMS has many attractive properties including high optical clarity and compliance, PDMS is very useful for cell culture applications; however, PDMS ...
Emi Sano, Chihiro Mori, Naoki Matsuoka, Yuka Ozaki, Keisuke Yagi, Aya Wada, Koichi Tashima, Shinsuke Yamasaki, Kana Tanabe, Kayo Yano, Yu-suke Torisawa   +10 more
doaj   +2 more sources

Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. [PDF]

Pharm Res, 2019
PURPOSE:The purpose of this study was to determine the impact of food on gastric pH and the ability of over the counter betaine hydrochloride (BHCl) acid to reacidify gastric pH after food-induced elevations in gastric pH.
Surofchy DD, Frassetto LA, Benet LZ.
europepmc   +3 more sources

Absorption of drugs from the rectum [PDF]

Archives of Disease in Childhood, 1943
J. W. Mackenzie
openalex   +3 more sources

Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets

Haematologica, 2022
The multidrug resistance protein 4 (MRP4) is highly expressed in platelets and several lines of evidence point to an impact on platelet function. MRP4 represents a transporter for cyclic nucleotides as well as for certain lipid mediators. The aim of the
Robert Wolf, Sophie Grammbauer, Raghavendra Palankar, Céline Tolksdorf, Eileen Moritz, Andreas Böhm, Mahmoud Hasan, Annika Hafkemeyer, Andreas Greinacher, Mladen V. Tzvetkov, Bernhard H. Rauch, Gabriele Jedlitschky   +11 more
doaj   +1 more source

Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics

Pharmaceutics, 2023
Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary tracer ...
Theodora Tzakri, Lara Rehenbrock, Stefan Senekowitsch, Adrian Rump, Philipp Schick, Julius Krause, Marie-Luise Kromrey, Michael Grimm, Werner Weitschies   +8 more
doaj   +1 more source

Gene Expression and Protein Abundance of Nuclear Receptors in Human Intestine and Liver: A New Application for Mass Spectrometry-Based Targeted Proteomics

Molecules, 2022
Background: Unwanted drug-drug interactions (DDIs), as caused by the upregulation of clinically relevant drug metabolizing enzymes and transporter proteins in intestine and liver, have the potential to threaten the therapeutic efficacy and safety of ...
Christoph Wenzel, Lisa Gödtke, Anne Reichstein, Markus Keiser, Diana Busch, Marek Drozdzik, Stefan Oswald   +6 more
doaj   +1 more source

An Advanced Bioreactor Simulating Dynamic Physiological Conditions in the Human Ascending Colon: MimiCol³

Pharmaceutics, 2022
In recent years, the colon has become a hot topic in biopharmaceutical research as several in vitro models of the human colon have been presented. A major focus is on the characterization of the microbiota and its capabilities.
Regine Beeck, Annemarie Dols, Felix Schneider, Dariah-Sohreh Seradj, Julius Krause, Philipp Schick, Werner Weitschies   +6 more
doaj   +1 more source

Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity

Expert Opinion on Drug Metabolism & Toxicology, 2021
Introduction: Physiological pH and chemical pKa are two sides of the same coin in defining the ionization of a drug in the human body. The Henderson-Hasselbalch equation and pH-partition hypothesis form the theoretical base to define the impact of pH-pKa
G. Lu, Xiusheng Miao, Liu Dou
semanticscholar   +1 more source

Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine

Pharmaceutics, 2023
Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs.
Stefan Senekowitsch, Constantin Foja, Toni Wildgrube, Philipp Schick, Christoph Rosenbaum, Julius Krause, Friederike Brokmann, Marie-Luise Kromrey, Stefan Engeli, Werner Weitschies, Michael Grimm   +10 more
doaj   +1 more source

Influence of Different Diets on the Degradation of Sulfasalazine by Colon Bacteria Determined Using MimiCol³

Pharmaceuticals, 2023
The microbiome of the colon is characterized by its great diversity. This varies not only intra- but also interindividually and is influenced by endogenous and exogenous factors, such as dietary and lifestyle factors.
Dariah-Sohreh Seradj, Regine Beeck, Annika Haase, Julius Krause, Philipp Schick, Werner Weitschies   +5 more
doaj   +1 more source