Engineering Analysis and Control of Transport Across the Intenstinal Mucosal Barrier [PDF]
, 2015 Transport phenomena in the intestinal lumen are highly significant to effective oral drug delivery, nutrient absorption, and interactions between microbes and intestinal tissue.
Carrier, Rebecca
core
Design and validation of a novel dosimetry phantom for motion management audits
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Background We present a novel phantom design for conducting end‐to‐end dosimetry audits for respiratory motion management of two anatomical treatment sites. The design enables radiochromic film measurements of the dose administered to the target throughout the respiratory cycle (motion‐included) and the dose delivered to the time‐averaged ...
Alex Burton +5 more
wiley +1 more source
Quaternization of high molecular weight chitosan for increasing intestinal drug absorption using Caco-2 cells as an in vitro intestinal model. [PDF]
Sci Rep, 2023 Wongwanakul R +6 more
europepmc +1 more source
Machine stability and dosimetry for ultra‐high dose rate FLASH radiotherapy human clinical protocol
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Background The FLASH effect, induced by ultra‐high dose rate (UHDR) irradiations, offers the potential to spare normal tissue while effectively treating tumors. It is important to achieve precise and accurate dose delivery and to establish reliable detector systems, particularly for clinical trials needed to help the clinical transfer of FLASH‐
Patrik Gonçalves Jorge +9 more
wiley +1 more source
MoleculesBiological variability poses significant challenges in the development of effective therapeutics, particularly when it comes to drug solubility and bioavailability. Poor solubility across varying physiological conditions often leads to reduced absorption
Yue Zhuo, Yong-Gang Zhao, Yun Zhang
doaj +1 more source
PSC-derived intestinal organoids with apical-out orientation as a tool to study nutrient uptake, drug absorption and metabolism. [PDF]
Front Mol Biosci, 2023 Kakni P +4 more
europepmc +1 more source
Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier +8 more
wiley +1 more source
Involvement of Transporters in Intestinal Drug-Drug Interactions of Oral Targeted Anticancer Drugs Assessed by Changes in Drug Absorption Time. [PDF]
Pharmaceutics, 2022 Malnoë D, Fardel O, Le Corre P.
europepmc +1 more source
Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis
Advanced Biology, EarlyView.Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard +7 more
wiley +1 more source
In-Vivo Analysis and Model-Based Prediction of Tensides' Influence on Drug Absorption. [PDF]
Molecules, 2021 Vitková Z +5 more
europepmc +1 more source