Preventive Effect of Metformin in Radiation‐Induced Xerostomia
Advanced Biology, EarlyView.Head and neck cancer patients who received radiotherapy complain of severe dry mouth due to damage to the salivary glands. Metformin is an antidiabetic drug, but its radio‐protective effect has been reported. It is confirmed that metformin protects the salivary glands from radiation and provides evidence for the use of metformin in cancer treatment in ...
Sungryeal Kim +5 more
wiley +1 more source
Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging. [PDF]
Biochem Pharmacol, 2022 Spruill ML +4 more
europepmc +1 more source
SMILES-Mamba: Chemical Mamba Foundation Models for Drug ADMET Prediction [PDF]
arXivIn drug discovery, predicting the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of small-molecule drugs is critical for ensuring safety and efficacy. However, the process of accurately predicting these properties is often resource-intensive and requires extensive experimental data.
arxiv
Advanced Biology, EarlyView.Coacervation driven by liquid‐liquid phase separation (LLPS) of biopolymers has garnered increasing attention in biology since this leads to the formation of membraneless organelles capable of performing essential yet largely unknown functions. This review highlights recent advances in coacervates (artificial condensates) composed of low‐molecular ...
Sayuri L. Higashi, Masato Ikeda
wiley +1 more source
Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin. [PDF]
Pharmaceutics, 2021 Dahan A +5 more
europepmc +1 more source
Integration of Genetic Algorithms and Deep Learning for the Generation and Bioactivity Prediction of Novel Tyrosine Kinase Inhibitors [PDF]
arXivThe intersection of artificial intelligence and bioinformatics has enabled significant advancements in drug discovery, particularly through the application of machine learning models. In this study, we present a combined approach using genetic algorithms and deep learning models to address two critical aspects of drug discovery: the generation of novel
arxiv
Advanced Biology, EarlyView.Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang +6 more
wiley +1 more source
Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation. [PDF]
Pharmaceutics, 2021 Dahan A, González-Álvarez I.
europepmc +1 more source
Toward Design Principles for Biomolecular Condensates for Metabolic Pathways
Advanced Biology, EarlyView.Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André +3 more
wiley +1 more source
Effective combination of cold physical plasma and chemotherapy against Ewing sarcoma cells in vitro
Scientific ReportsEwing's sarcoma (ES) is the second most common bone tumor in children and adolescents and is highly malignant. Although the new chemotherapy has significantly improved the survival rate for ES from about 10 to 75%, the survival rate for metastatic tumors
Andreas Nitsch +9 more
doaj +1 more source