Results 21 to 30 of about 5,071,662 (140)
Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research
Pharmaceutics, 2022 Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation.
Stefan Senekowitsch +15 more
doaj +1 more source
Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions
Drug Metabolism And Disposition, 2020 The organic anion transporting polypeptide (OATP)2B1 is localized on the basolateral membrane of hepatocytes and is expressed in enterocytes. Based on its distribution pattern and functional similarity to OATP1B-type transporters, OATP2B1 might have a ...
Mingqing Chen +6 more
semanticscholar +1 more source
Pharmaceutics, 2023 The characterization of intravitreal dosage forms with regard to their behavior in vivo is usually explored in preclinical development through animal studies. In vitro vitreous substitutes (VS) to simulate the vitreous body for preclinical investigations
Tobias Auel +6 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Genome-wide association studies have identified an association between isobutyrylcarnitine (IBC) and organic cation transporter 1 (OCT1) genotypes. Higher IBC blood concentrations in humans with active OCT1 genotypes and experimental studies with mouse ...
Ole Jensen +5 more
doaj +1 more source
Influence of Siluron® insertion on model drug distribution in the simulated vitreous body
Current Directions in Biomedical Engineering, 2016 Biorelevant in vitro test systems may be helpful to understand the in vivo behaviour of modern intravitreal dosage forms such as implants and injections.
Stein Sandra +3 more
doaj +1 more source
Various effects of repeated rifampin dosing on coproporphyrin levels in humans
Clinical and Translational Science, 2023 In recent years, the identification of endogenous substrates as biomarkers became an uprising topic. Particularly coproporphyrins (CPs), byproducts of heme biosynthesis, are intensely investigated as biomarkers for predicting interactions with the ...
Jonny Kinzi +5 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Exogenous glucocorticoids increase the risk for osteoporosis, but the role of endogenous glucocorticoids remains elusive. Here, we describe the generation and validation of a loss- and a gain-of-function model of the cortisol producing enzyme 11β-HSD1 ...
Angelique Kragl +10 more
doaj +1 more source
Organic Cation Transporter 1 an Intestinal Uptake Transporter: Fact or Fiction?
Frontiers in Pharmacology, 2021 Intestinal transporter proteins are known to affect the pharmacokinetics and in turn the efficacy and safety of many orally administered drugs in a clinically relevant manner.
Christoph Wenzel +2 more
doaj +1 more source
Pharmaceutics, 2022 Postoperative restenosis in patients with external ear canal (EEC) atresia or stenosis is a common complication following canaloplasty. Our aim in this study was to explore the feasibility of using a three dimensionally (3D)-printed, patient ...
Farnaz Matin-Mann +11 more
doaj +1 more source
A molecular communications model for drug delivery [PDF]
IEEE Trans Nanobioscience. 2015 Dec;14(8):935-45, 2018 This paper considers the scenario of a targeted drug delivery system, which consists of deploying a number of biological nanomachines close to a biological target (e.g. a tumor), able to deliver drug molecules in the diseased area. Suitably located transmitters are designed to release a continuous flow of drug molecules in the surrounding environment ...
arxiv +1 more source