Results 21 to 30 of about 750,762 (351)
Influence of Siluron® insertion on model drug distribution in the simulated vitreous body
Current Directions in Biomedical Engineering, 2016 Biorelevant in vitro test systems may be helpful to understand the in vivo behaviour of modern intravitreal dosage forms such as implants and injections.
Stein Sandra +3 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Genome-wide association studies have identified an association between isobutyrylcarnitine (IBC) and organic cation transporter 1 (OCT1) genotypes. Higher IBC blood concentrations in humans with active OCT1 genotypes and experimental studies with mouse ...
Ole Jensen +5 more
doaj +1 more source
Various effects of repeated rifampin dosing on coproporphyrin levels in humans
Clinical and Translational Science, 2023 In recent years, the identification of endogenous substrates as biomarkers became an uprising topic. Particularly coproporphyrins (CPs), byproducts of heme biosynthesis, are intensely investigated as biomarkers for predicting interactions with the ...
Jonny Kinzi +5 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Exogenous glucocorticoids increase the risk for osteoporosis, but the role of endogenous glucocorticoids remains elusive. Here, we describe the generation and validation of a loss- and a gain-of-function model of the cortisol producing enzyme 11β-HSD1 ...
Angelique Kragl +10 more
doaj +1 more source
Absorption reconstruction improves biodistribution assessment of fluorescent nanoprobes using hybrid Fluorescence-mediated tomography [PDF]
, 2014 Aim: Fluorescence-mediated tomography (FMT) holds potential for accelerating diagnostic and theranostic drug development. However, for proper quantitative fluorescence reconstruction, knowledge on optical scattering and absorption, which are highly ...
Barth, S. +8 more
core +4 more sources
Organic Cation Transporter 1 an Intestinal Uptake Transporter: Fact or Fiction?
Frontiers in Pharmacology, 2021 Intestinal transporter proteins are known to affect the pharmacokinetics and in turn the efficacy and safety of many orally administered drugs in a clinically relevant manner.
Christoph Wenzel +2 more
doaj +1 more source
A two-dimensional mathematical model of percutaneous drug absorption [PDF]
, 2004 Background When a drug is applied on the skin surface, the concentration of the drug accumulated in the skin and the amount of the drug eliminated into the blood vessel depend on the value of a parameter, r.
AB Gumel +9 more
core +3 more sources
Pharmaceutics, 2022 Postoperative restenosis in patients with external ear canal (EEC) atresia or stenosis is a common complication following canaloplasty. Our aim in this study was to explore the feasibility of using a three dimensionally (3D)-printed, patient ...
Farnaz Matin-Mann +11 more
doaj +1 more source
Direct measurement of molecular mobility and crystallisation of amorphous pharmaceuticals using terahertz spectroscopy. [PDF]
, 2016 Despite much effort in the area, no comprehensive understanding of the formation and behaviour of amorphous solids has yet been achieved. This severely limits the industrial application of such materials, including drug delivery where, in principle ...
core +2 more sources
Doxorubicin-Loaded Human Serum Albumin Submicron Particles: Preparation, Characterization and In Vitro Cellular Uptake [PDF]
, 2020 Doxorubicin (DOX) is an effective anthracycline antibiotic drug which is commonly used in a broad range cancer therapy. However, due to dose depending side effects and toxicity to non-cancerous tissues, its clinical applications are restricted.
Bäumler, Hans +7 more
core +1 more source