Results 21 to 30 of about 5,380,439 (377)

Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets

Haematologica, 2022
The multidrug resistance protein 4 (MRP4) is highly expressed in platelets and several lines of evidence point to an impact on platelet function. MRP4 represents a transporter for cyclic nucleotides as well as for certain lipid mediators. The aim of the
Robert Wolf, Sophie Grammbauer, Raghavendra Palankar, Céline Tolksdorf, Eileen Moritz, Andreas Böhm, Mahmoud Hasan, Annika Hafkemeyer, Andreas Greinacher, Mladen V. Tzvetkov, Bernhard H. Rauch, Gabriele Jedlitschky   +11 more
doaj   +1 more source

Gene Expression and Protein Abundance of Nuclear Receptors in Human Intestine and Liver: A New Application for Mass Spectrometry-Based Targeted Proteomics

Molecules, 2022
Background: Unwanted drug-drug interactions (DDIs), as caused by the upregulation of clinically relevant drug metabolizing enzymes and transporter proteins in intestine and liver, have the potential to threaten the therapeutic efficacy and safety of ...
Christoph Wenzel, Lisa Gödtke, Anne Reichstein, Markus Keiser, Diana Busch, Marek Drozdzik, Stefan Oswald   +6 more
doaj   +1 more source

Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics

Pharmaceutics, 2023
Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary tracer ...
Theodora Tzakri, Lara Rehenbrock, Stefan Senekowitsch, Adrian Rump, Philipp Schick, Julius Krause, Marie-Luise Kromrey, Michael Grimm, Werner Weitschies   +8 more
doaj   +1 more source

Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity

Expert Opinion on Drug Metabolism & Toxicology, 2021
Introduction: Physiological pH and chemical pKa are two sides of the same coin in defining the ionization of a drug in the human body. The Henderson-Hasselbalch equation and pH-partition hypothesis form the theoretical base to define the impact of pH-pKa
G. Lu, Xiusheng Miao, Liu Dou
semanticscholar   +1 more source

An Advanced Bioreactor Simulating Dynamic Physiological Conditions in the Human Ascending Colon: MimiCol³

Pharmaceutics, 2022
In recent years, the colon has become a hot topic in biopharmaceutical research as several in vitro models of the human colon have been presented. A major focus is on the characterization of the microbiota and its capabilities.
Regine Beeck, Annemarie Dols, Felix Schneider, Dariah-Sohreh Seradj, Julius Krause, Philipp Schick, Werner Weitschies   +6 more
doaj   +1 more source

Drug Absorption Studies: In Situ, In Vitro and In Silico Models

, 2021
Perfused Organ Level/In Situ Techniques.- Models for Skin Absorption and Skin Toxicity Testing.- Models of the Small Intestine.- Drug Absorption from the Colon In Situ.- In Vivo and In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosa.-
C. Ehrhardt, Kwang-Jin Kim
semanticscholar   +1 more source

Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine

Pharmaceutics, 2023
Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs.
Stefan Senekowitsch, Constantin Foja, Toni Wildgrube, Philipp Schick, Christoph Rosenbaum, Julius Krause, Friederike Brokmann, Marie-Luise Kromrey, Stefan Engeli, Werner Weitschies, Michael Grimm   +10 more
doaj   +1 more source

Influence of Different Diets on the Degradation of Sulfasalazine by Colon Bacteria Determined Using MimiCol³

Pharmaceuticals, 2023
The microbiome of the colon is characterized by its great diversity. This varies not only intra- but also interindividually and is influenced by endogenous and exogenous factors, such as dietary and lifestyle factors.
Dariah-Sohreh Seradj, Regine Beeck, Annika Haase, Julius Krause, Philipp Schick, Werner Weitschies   +5 more
doaj   +1 more source

The EyeFlowCell: Development of a 3D-Printed Dissolution Test Setup for Intravitreal Dosage Forms

Pharmaceutics, 2021
An in vitro dissolution model, the so-called EyeFlowCell (EFC), was developed to test intravitreal dosage forms, simulating parameters such as the gel-like consistency of the vitreous body.
Tobias Auel, Linus Großmann, Lukas Schulig, Werner Weitschies, Anne Seidlitz   +4 more
doaj   +1 more source

3D-Printing of Drug-Eluting Implants: An Overview of the Current Developments Described in the Literature

Molecules, 2021
The usage of 3D-printing for drug-eluting implants combines the advantages of a targeted local drug therapy over longer periods of time at the precise location of the disease with a manufacturing technique that easily allows modifications of the implant ...
Vanessa Domsta, Anne Seidlitz
doaj   +1 more source