Results 341 to 350 of about 5,685,542 (420)

Urine‐Stable Aptamer‐Conjugated Gold Nanorods for the Early Detection of High‐Grade Bladder Cancer Residual Disease

Advanced Healthcare Materials, EarlyView.
Aptamer (A) conjugated gold nanorods (B) for the recognition of bladder cancer cells expressing the integrin α5β1 (C) and the visualization of the targeted GNRs@Chit‐Apt‐Itg by photoacoustic imaging at the surface of the orthotopic bladder cancer in the preclinical model (D).
Chiara Venegoni, Silvia Tortorella, Alessandra Caliendo, Irene Locatelli, Alessia Di Coste, Erica Locatelli, Filippo Capancioni, Emanuela Bua, Simona Camorani, Andrea Salonia, Francesco Montorsi, Jithin Jose, Marco Moschini, Laura Cerchia, Mauro Comes Franchini, Massimo Alfano   +15 more
wiley   +1 more source

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

Advanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li, Andi Dian Permana, Juan Domínguez‐Robles, Muh Nur Amir, Habibie Habibie, Qonita Kurnia Anjani, Li Zhao, Natalia Moreno‐Castellanos, Ryan F Donnelly, Eneko Larrañeta   +9 more
wiley   +1 more source

Multiscale Thermal Analysis of Gold Nanostars in 3D Tumor Spheroids: Integrating Cellular‐Level Photothermal Effects and Nanothermometry via X‐Ray Spectroscopy

Advanced Healthcare Materials, EarlyView.
This study investigates nanoscale temperatures generated by photoexcited gold nanostars and their correlation with microscale thermal damage at the cellular level. Using X‐ray absorption spectroscopy and confocal microscopy in 3D cancer spheroids, it assesses localized heating effects and examines tumor cell structure and integrity, offering insights ...
Rosalía López‐Méndez, Anastasiia Dubrova, Javier Reguera, Rául Magro, Fátima Esteban‐Betegón, Ana Parente, Miguel Ángel García, Julio Camarero, Emiliano Fonda, Claire Wilhelm, Álvaro Muñoz‐Noval, Ana Espinosa   +11 more
wiley   +1 more source

In Situ‐Gelling Antimicrobial Poly(oligoethylene glycol methacrylate)‐Based Hydrogels Integrating Bound Quaternary Ammonia Compounds and Antibiotic Functionalities for Effective Infected Wound Healing

Advanced Healthcare Materials, EarlyView.
In situ‐gelling poly(oligoethylene glycol methacrylate) (POEGMA)‐based hydrogels exhibit broad‐spectrum antibacterial activity against both gram‐positive and gram‐negative bacteria based on the dual covalent attachment of quaternary ammonium (QA) groups and the antibiotic ciprofloxacin (CIP) into the hydrogel networks, enabling effective in vivo burn ...
Fei Xu, Evelyn Cudmore, Sadru‐Dean Walji, Lei Zhang, Meghan Kostashuk, Isabella Jun, Gurpreet Randhawa, Zhicheng Pan, Todd Hoare   +8 more
wiley   +1 more source

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Drug Absorption

The ADME Encyclopedia, 2018
Alan Talevi, Carolina L. Bellera
openaire   +2 more sources

Experimental modelling of drug absorption and drug absorption interactions

International Journal of Pharmaceutics, 1986
Abstract Five experimental models of drug absorption were evaluated using chloroquine and phenobarbitone as tracer drugs. Their absorption was followed at different pH values and in the absence and presence of the interactants kaolin and activated charcoal.
McElnay, James, Sidahmed, A.M., Darcy, P.F.   +2 more
openaire   +2 more sources

Percutaneous Absorption of Drugs

Clinical Pharmacokinetics, 1992
The skin is an evolutionary masterpiece of living tissue which is the final control unit for determining the local and systemic availability of any drug which must pass into and through it. In vivo in humans, many factors will affect the absorption of drugs. These include individual biological variation and may be influenced by race.
Howard I. Maibach, Ronald C. Wester
openaire   +2 more sources

EPIDERMAL ABSORPTION OF DRUGS

Archives of Dermatology, 1948
CERTAIN ethylene series are absorbable when applied on the intact skin by gentle spreading. This has suggested the possibility of the use of one of these glycols alone or in mixture with other agents, as a vehicle or carrier for drugs, to promote or enhance their percutaneous absorption.
F. P. Luduena, Jean K. Fellows, R. L. Driver   +2 more
openaire   +3 more sources

THE ABSORPTION OF DRUGS [PDF]

JAMA: The Journal of the American Medical Association, 1923
Most of the drugs employed as therapeutic agents depend on their entrance into the blood stream, either in sufficient concentration or in sufficient total quantity, for the development of their therapeutic actions. Adequate knowledge of their absorption is therefore of fundamental importance to the development of a rational drug therapy.
openaire   +1 more source