Results 351 to 360 of about 5,685,542 (420)

Drug Absorption II: Effect of Fasting on Intestinal Drug Absorption

Journal of Pharmaceutical Sciences, 1969
The effects of fasting on the intestinal absorption profiles of salicylic acid, barbital, haloperidol, and chlorpromazine were studied in anesthetized rats. The in situ technique employed in this study yielded absorption rate constants which were realistic and comparable to those observed following oral drug administration. The weak acids, barbital and
Louis Diamond, Norman F. Billups, J.T. Doluisio, G.H. Tan   +3 more
openaire   +2 more sources

Percutaneous Absorption of Drugs

Annual Review of Pharmacology and Toxicology, 1989
Some practical applications of basic information in percutaneous absorption have been reviewed. Drug release from vehicles is discussed in relation to glucocorticosteroids. Penetration enhancers are reviewed with emphasis on the need for further investigations and applications of enhancers for clinical use.
openaire   +3 more sources

Migraine and Drug Absorption

Clinical Pharmacokinetics, 1978
The majority of migraine attacks are associated with gastrointestinal symptoms which add considerably to the distress and inconvenience caused by the headache. When salicylate absorption from effervescent aspirin tablets was studied during migraine, the rate of absorption was found to be reduced relative to that found in non-migrainous volunteers and ...
openaire   +2 more sources

A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption—Part II: Gastrointestinal Transit Time

AAPS Journal, 2016
This study aimed to conduct a quantitative meta-analysis for the values of, and variability in, gastrointestinal (GI) transit times of non-disintegrating single-unit (“tablet”) and multiple-unit (“pellets/multi-unit tablet”) solid dosage forms ...
A. Abuhelwa, D. Foster, R. Upton
semanticscholar   +1 more source

HYPERGLYCAEMIA AND ABSORPTION OF SULPHONYLUREA DRUGS

The Lancet, 1989
To examine whether hyperglycaemia impairs the absorption of sulphonylurea agents, glipizide, which is rapidly and completely absorbed, was measured in plasma from 12 healthy young subjects during various levels of experimentally-induced hyperglycaemia.
Groop, LeifC., Defronzo, RalphA., Luzi, L., Melander, A.   +3 more
openaire   +3 more sources

Potential of Liposomes for Enhancement of Oral Drug Absorption.

Current Drug Delivery, 2017
Oral administration of medication is the first option when patient compliance is considered. However, many barriers face oral absorption of drugs that limit bioavailability in about 90% of therapeutic agents.
Marjan Daeihamed, S. Dadashzadeh, A. Haeri, Masoud Akhlaghi   +3 more
semanticscholar   +1 more source

In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models.

Molecular Pharmaceutics, 2016
Gastrointestinal (GI) drug absorption is a complex process determined by formulation, physicochemical and biopharmaceutical factors, and GI physiology.
E. Sjögren, Helena Thörn, C. Tannergren   +2 more
semanticscholar   +1 more source

SUBLINGUAL ABSORPTION OF DRUGS: MORPHINE

Archives of Internal Medicine, 1928
Paulson,1being impressed by the accessibility, the thin mucous membrane and the abundant blood supply of the sublingual space, was one of the first to recommend the sublingual administration of drugs. His experience led him to believe that drugs were rapidly absorbed when administered in this manner.
D. Davis, D. Ayman
openaire   +3 more sources

Development of a Unified Dissolution and Precipitation Model and Its Use for the Prediction of Oral Drug Absorption.

Molecular Pharmaceutics, 2016
Drug absorption is a complex process involving dissolution and precipitation, along with other kinetic processes. The purpose of this work was to (1) establish an in vitro methodology to study dissolution and precipitation in early stages of drug ...
Paulina Jakubiak, Björn Wagner, H. Grimm, Jeannine Petrig-Schaffland, F. Schuler, R. Alvarez-Sánchez   +5 more
semanticscholar   +1 more source

Drug absorption in celiac disease

American Journal of Health-System Pharmacy, 2013
Published evidence on established and theorized effects of celiac disease on drug absorption and pharmacokinetics is reviewed.Patients with celiac disease develop a variety of gastric disorders requiring oral medications, but the impact of damage to intestinal villi and other celiac disease sequelae on drug absorption remains poorly understood.
Tran H. Tran, Robert A. Mangione, Candace Smith   +2 more
openaire   +2 more sources