Results 31 to 40 of about 5,685,542 (420)
A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption [PDF]
, 2012 Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo ...
Adibkia, Khosro +6 more
core +3 more sources
Course of disease and risk factors for hospitalization in outpatients with a SARS-CoV-2 infection
Scientific Reports, 2022 We analyzed symptoms and comorbidities as predictors of hospitalization in 710 outpatients in North-East Germany with PCR-confirmed SARS-CoV-2 infection.
Eik Schäfer +18 more
doaj +1 more source
Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research
Pharmaceutics, 2022 Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation.
Stefan Senekowitsch +15 more
doaj +1 more source
Prediction of the permeability of neutral drugs inferred from their solvation properties [PDF]
, 2015 Determination of drug absorption is an important component of the drug discovery and development process in that it plays a key role in the decision to promote drug candidates to clinical trials.
Milanetti, Edoardo +2 more
core +1 more source
Pharmaceutics, 2023 The characterization of intravitreal dosage forms with regard to their behavior in vivo is usually explored in preclinical development through animal studies. In vitro vitreous substitutes (VS) to simulate the vitreous body for preclinical investigations
Tobias Auel +6 more
doaj +1 more source
A general model of coupled drug release and tissue absorption for drug delivery devices [PDF]
, 2015 In this paper we present a general model of drug release from a drug delivery device and the subsequent transport in biological tissue. The model incorporates drug diffusion, dissolution and solubility in the polymer coating, coupled with diffusion ...
Mcginty, Sean, Pontrelli, Giuseppe
core +1 more source
Frontiers in Pharmacology, 2021 Genome-wide association studies have identified an association between isobutyrylcarnitine (IBC) and organic cation transporter 1 (OCT1) genotypes. Higher IBC blood concentrations in humans with active OCT1 genotypes and experimental studies with mouse ...
Ole Jensen +5 more
doaj +1 more source
A two-dimensional mathematical model of percutaneous drug absorption [PDF]
, 2004 Background When a drug is applied on the skin surface, the concentration of the drug accumulated in the skin and the amount of the drug eliminated into the blood vessel depend on the value of a parameter, r.
AB Gumel +9 more
core +3 more sources
Influence of Siluron® insertion on model drug distribution in the simulated vitreous body
Current Directions in Biomedical Engineering, 2016 Biorelevant in vitro test systems may be helpful to understand the in vivo behaviour of modern intravitreal dosage forms such as implants and injections.
Stein Sandra +3 more
doaj +1 more source
Various effects of repeated rifampin dosing on coproporphyrin levels in humans
Clinical and Translational Science, 2023 In recent years, the identification of endogenous substrates as biomarkers became an uprising topic. Particularly coproporphyrins (CPs), byproducts of heme biosynthesis, are intensely investigated as biomarkers for predicting interactions with the ...
Jonny Kinzi +5 more
doaj +1 more source