Results 51 to 60 of about 5,380,340 (278)

Predictive Performance of Physiologically Based Pharmacokinetic Models for the Effect of Food on Oral Drug Absorption: Current Status

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2017
A comprehensive search in literature and published US Food and Drug Administration reviews was conducted to assess whether physiologically based pharmacokinetic (PBPK) modeling could be prospectively used to predict clinical food effect on oral drug ...
Mengyao Li   +3 more
semanticscholar   +1 more source

Fine-Tuning BERT for Automatic ADME Semantic Labeling in FDA Drug Labeling to Enhance Product-Specific Guidance Assessment [PDF]

open access: yesarXiv, 2022
Product-specific guidances (PSGs) recommended by the United States Food and Drug Administration (FDA) are instrumental to promote and guide generic drug product development. To assess a PSG, the FDA assessor needs to take extensive time and effort to manually retrieve supportive drug information of absorption, distribution, metabolism, and excretion ...
arxiv  

A two-phase two-layer model for transdermal drug delivery and percutaneous absorption [PDF]

open access: yesMathematical Biosciences, 257, pp. 96-103, 2014, 2014
One of the promising frontiers of bioengineering is the controlled release of a therapeuticdrug from a vehicle across the skin (transdermal drug delivery). In order to study the complete process, a two-phase mathematical model describing the dynamics of a substance between two coupled media of different properties and dimensions is presented.
arxiv   +1 more source

Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms.

open access: yesLab on a Chip, 2017
Biocompatible polymers, such as polydimethylsiloxane (PDMS), are the materials of choice for creating organ-on-a-chip microfluidic platforms. Desirable qualities include ease of fabrication, optical clarity, and hydrophobicity, the latter of which ...
Venktesh S. Shirure, Steven C. George
semanticscholar   +1 more source

First Principle Simulation of Coated Hydroxychloroquine on Ag, Au and Pt Nanoparticle as a Potential Candidate for Treatment of SARS-CoV-2 (COVID-19) [PDF]

open access: yes, 2020
The {\it{in vitro}} antiviral activity of Hydroxychloroquine (HCQ) and chloroquine (CQ) against SARS-CoV-2 from the first month of pandemic proposed these drugs as the appropriate therapeutic candidate, although their side effect directed the clinical test toward optimizing the safe utilization strategies.
arxiv   +1 more source

The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions

open access: yesExpert Opinion on Drug Metabolism & Toxicology, 2017
Introduction: The in vivo fate and effectiveness of a drug depends highly on its absorption, distribution, metabolism, excretion and toxicity (ADME-Tox).
Daniella Kovacsics   +2 more
semanticscholar   +1 more source

Cow Milk and Intestinal Epithelial Cell-derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery

open access: yesPharmaceutics, 2020
Ingestion is the preferred way for drug administration. However, many drugs have poor oral bioavailability, warranting the use of injections. Extracellular vesicles (EVs) from cow milk have shown potential utility in improving oral drug bioavailability ...
Greta Carobolante   +3 more
doaj   +1 more source

Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media

open access: yesPharmaceutics, 2022
The poor solubility and permeability of compounds beyond Lipinski’s Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of ...
Dong Ye   +9 more
doaj   +1 more source

MR imaging of model drug distribution in simulated vitreous

open access: yesCurrent Directions in Biomedical Engineering, 2015
The in vitro and in vivo characterization of intravitreal injections plays an important role in developing innovative therapy approaches. Using the established vitreous model (VM) and eye movement system (EyeMoS) the distribution of contrast agents with ...
Stein Sandra   +8 more
doaj   +1 more source

Designing Covalent Organic Framework-based Light-driven Microswimmers towards Intraocular Theranostic Applications [PDF]

open access: yesarXiv, 2023
Even micromachines with tailored functionalities enable targeted therapeutic applications in biological environments, their controlled motion in biological media and drug delivery functions usually require sophisticated designs and complex propulsion apparatuses for practical applications.
arxiv  

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