Results 51 to 60 of about 750,762 (351)

Drug Absorption from Large Intestine: Physicochemical Factors Governing Drug Absorption.

Biological and Pharmaceutical Bulletin, 1994
Profiles of absorption versus drug molecular weight and absorption versus drug lipophilicity were investigated in both the small and large intestines of rats by an in situ loop method. The absorption-molecular weight profiles examined using different-sized polyethylene glycols (PEGs) were different between the small and large intestines; the large ...
T, Kimura, K, Sudo, Y, Kanzaki, K, Miki, Y, Takeichi, Y, Kurosaki, T, Nakayama   +6 more
openaire   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation [PDF]

, 2018
During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of
Bailey, Bon, Cox, Darwich, Dorey, Duwal, Ette, Fink, Jamei, Jamei, Jeunesse, Li, Li, Lin, Maaland, Margolskee, Margolskee, Martinez, Martinez, Martinez, Mochel, Mochel, Mochel, Mochel, Mochel, Mould, Ogungbenro, Pade, Pade, Paulson, Pelligand, Rey, Rostami-Hodjegan, Sheiner, Silber, Sjögren, Toutain, Tsamandouras, T’jollyn, Willmann, Zhuang   +40 more
core   +4 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Ex vivo perfusion model of mouse liver and its application to analyze the effects of OCT1 deficiency

Frontiers in Pharmacology
IntroductionThe liver plays a critical role in drug pharmacokinetics. In in vivo experiments, it is difficult to isolate the liver’s contribution to drug systemic concentrations from that of the intestine and kidneys.
Vincent Rönnpagel, Felix Morof, Giuliano Ciarimboli, Markus Grube, Marleen J. Meyer-Tönnies, Mladen V. Tzvetkov   +5 more
doaj   +1 more source

Automated Real-Time Tumor Pharmacokinetic Profiling in 3D Models: A Novel Approach for Personalized Medicine

Pharmaceutics, 2020
Cancer treatment often lacks individual dose adaptation, contributing to insufficient efficacy and severe side effects. Thus, personalized approaches are highly desired.
Jan F. Joseph, Leonie Gronbach, Jill García-Miller, Leticia M. Cruz, Bernhard Wuest, Ulrich Keilholz, Christian Zoschke, Maria K. Parr   +7 more
doaj   +1 more source

Portable Iontophoresis Device for Efficient Drug Delivery

Bioengineering, 2023
The timely delivery of drugs to specific locations in the body is imperative to ensure the efficacy of treatment. This study introduces a portable facial device that can deliver drugs efficiently using iontophoresis.
Moonjeong Bok, Young Il Kwon, Zheng Min Huang, Eunju Lim   +3 more
doaj   +1 more source

Pharmacokinetics of dexamethasone in broiler chickens [PDF]

, 2012
Dexamethasone (DEX) is a synthetic derivate of cortisol and is one of the most potent glucocorticoids in man and animal. It is well known as an anti-inflammatory drug in many species. In poultry, however, data on the use of DEX are scarce.
Croubels, Siska, De Backer, Patrick, De Baere, Siegrid, Plessers, Elke, Watteyn, Anneleen, Wyns, Heidi   +5 more
core   +1 more source

The preparation, characterization, and pharmacokinetic studies of chitosan nanoparticles loaded with paclitaxel/dimethyl-β-cyclodextrin inclusion complexes. [PDF]

, 2015
A novel biocompatible and biodegradable drug-delivery nanoparticle (NP) has been developed to minimize the severe side effects of the poorly water-soluble anticancer drug paclitaxel (PTX) for clinical use.
Chen, R, Chen, YZ, Gao, F, Lou, KY, Wang, Y, Ye, YJ   +5 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source