Results 71 to 80 of about 5,685,542 (420)
Proteome-informed machine learning studies of cocaine addiction [PDF]
arXiv, 2021 Cocaine addiction accounts for a large portion of substance use disorders and threatens millions of lives worldwide. There is an urgent need to come up with efficient anti-cocaine addiction drugs. Unfortunately, no medications have been approved by the Food and Drug Administration (FDA), despite the extensive effort in the past few decades.
arxiv
Magnetic hydrogels derived from polysaccharides with improved specific power absorption: potential devices for remotely triggered drug delivery [PDF]
J. Phys. Chem. B, 2010, 114 (37), pp 12002--12007, 2011 We report on novel ferrogels derived from polysaccharides (sodium alginate and chitosan) with embedded iron oxide nanoparticles synthesized in situ and their combination with thermally responsive poly (N-isopropylacrylamide) for externally-driven drug release using AC magnetic fields.
arxiv +1 more source
Colonic Absorption of Antiepileptic Agents [PDF]
, 1997 Purpose: To evaluate a canine intestinal access-port model to study colonic absorption of drugs. The antiepileptic drugs phenytoin and gabapentin were chosen to study absorption of a lipophilic and hydrophilic compound, respectively. Methods: Drug plasma
Fleisher, David +2 more
core +1 more source
Molecular Pharmaceutics, 2018 The ability of lipid-based formulations (LBFs) to increase the solubilization, and prolong the supersaturation, of poorly water-soluble drugs (PWSDs) in the gastrointestinal (GI) fluids has generated significant interest in the past decade. One mechanism
Estelle J A Suys +3 more
semanticscholar +1 more source
Poly(Vinylalcohol-Co-Vinyloleate) for the Preparation of Micelles Enhancing Retinyl Palmitate Transcutaneous Permeation [PDF]
, 2002 The amphiphilic properties of poly(vinylalcohol) substituted with oleic acid was evaluated to assess the possibility to prepare polymeric micelles in an aqueous phase containing a hydrophobic core able to host lipophilic drugs such as retinyl palmitate ...
Barbara Luppi +6 more
core +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2017 A comprehensive search in literature and published US Food and Drug Administration reviews was conducted to assess whether physiologically based pharmacokinetic (PBPK) modeling could be prospectively used to predict clinical food effect on oral drug ...
Mengyao Li +3 more
semanticscholar +1 more source
Fine-Tuning BERT for Automatic ADME Semantic Labeling in FDA Drug Labeling to Enhance Product-Specific Guidance Assessment [PDF]
arXiv, 2022 Product-specific guidances (PSGs) recommended by the United States Food and Drug Administration (FDA) are instrumental to promote and guide generic drug product development. To assess a PSG, the FDA assessor needs to take extensive time and effort to manually retrieve supportive drug information of absorption, distribution, metabolism, and excretion ...
arxiv
A two-phase two-layer model for transdermal drug delivery and percutaneous absorption [PDF]
Mathematical Biosciences, 257, pp. 96-103, 2014, 2014 One of the promising frontiers of bioengineering is the controlled release of a therapeuticdrug from a vehicle across the skin (transdermal drug delivery). In order to study the complete process, a two-phase mathematical model describing the dynamics of a substance between two coupled media of different properties and dimensions is presented.
arxiv +1 more source
Lab on a Chip, 2017 Biocompatible polymers, such as polydimethylsiloxane (PDMS), are the materials of choice for creating organ-on-a-chip microfluidic platforms. Desirable qualities include ease of fabrication, optical clarity, and hydrophobicity, the latter of which ...
Venktesh S. Shirure, Steven C. George
semanticscholar +1 more source
First Principle Simulation of Coated Hydroxychloroquine on Ag, Au and Pt Nanoparticle as a Potential Candidate for Treatment of SARS-CoV-2 (COVID-19) [PDF]
, 2020 The {\it{in vitro}} antiviral activity of Hydroxychloroquine (HCQ) and chloroquine (CQ) against SARS-CoV-2 from the first month of pandemic proposed these drugs as the appropriate therapeutic candidate, although their side effect directed the clinical test toward optimizing the safe utilization strategies.
arxiv +1 more source