Results 81 to 90 of about 5,685,542 (420)
IN VITRO ABSORPTION STUDY OF CARBAMAZEPINE SOLID DISPERSION USING EVERTED GUT SAC METHOD [PDF]
, 2013 The oral Bioavailability of BCS (Bio Pharmaceutical Classification System) class II drug with poor solubility and reasonable permeability is limited by drug dissolution.
Ghaie, Pankaj +5 more
core +2 more sources
Expert Opinion on Drug Metabolism & Toxicology, 2017 Introduction: The in vivo fate and effectiveness of a drug depends highly on its absorption, distribution, metabolism, excretion and toxicity (ADME-Tox).
Daniella Kovacsics +2 more
semanticscholar +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Pharmaceutics, 2020 Ingestion is the preferred way for drug administration. However, many drugs have poor oral bioavailability, warranting the use of injections. Extracellular vesicles (EVs) from cow milk have shown potential utility in improving oral drug bioavailability ...
Greta Carobolante +3 more
doaj +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
MR imaging of model drug distribution in simulated vitreous
Current Directions in Biomedical Engineering, 2015 The in vitro and in vivo characterization of intravitreal injections plays an important role in developing innovative therapy approaches. Using the established vitreous model (VM) and eye movement system (EyeMoS) the distribution of contrast agents with ...
Stein Sandra +8 more
doaj +1 more source
Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media
Pharmaceutics, 2022 The poor solubility and permeability of compounds beyond Lipinski’s Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of ...
Dong Ye +9 more
doaj +1 more source
Designing Covalent Organic Framework-based Light-driven Microswimmers towards Intraocular Theranostic Applications [PDF]
arXiv, 2023 Even micromachines with tailored functionalities enable targeted therapeutic applications in biological environments, their controlled motion in biological media and drug delivery functions usually require sophisticated designs and complex propulsion apparatuses for practical applications.
arxiv
Variational finite element method to study the absorption rate of drug at various compartments through transdermal drug delivery system [PDF]
, 2015 Background: The delivery of drugs through dermal layers known as transdermal drug delivery is one of the important contributions in medical practice. It represents an alternative to oral drug delivery and is poised to provide a substitute to hypodermic ...
Khanday, MA, Rafiq, A
core +3 more sources
Predicting Oral Drug Absorption: Mini Review on Physiologically-Based Pharmacokinetic Models
Pharmaceutics, 2017 Most marketed drugs are administered orally, despite the complex process of oral absorption that is difficult to predict. Oral bioavailability is dependent on the interplay between many processes that are dependent on both compound and physiological ...
Louis Lin, H. Wong
semanticscholar +1 more source