Results 231 to 240 of about 932,717 (306)

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK pathways

Arthritis &Rheumatology, Accepted Article.
Introduction Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

Illicit drug abuse and complexity of tibial shaft fracture based on AO/OTA classification: Is there any connection? [PDF]

J Exp Orthop
Sharafi A, Ghaderi A, Shahbazi P, Ghaseminejad-Raeini A, Ramezani A, Soleimani M, Talebiyan P, Shafiei SH.   +7 more
europepmc   +1 more source

“You're this person who's providing light”: Embodied responses to information loss and transition within LGBTQIA+ communities

Journal of the Association for Information Science and Technology, EarlyView.
Abstract This paper reports on findings from 15 semi‐structured interviews with LGBTQIA+ individuals within the United States who have experienced the loss of one or more LGBTQIA+ information spaces. The paper specifically focuses on how such losses occurred and the information transitions experienced by the participants in response to this loss ...
Travis L. Wagner, Vanessa L. Kitzie
wiley   +1 more source

Excipient Lung Disease and Fatal Outcome Among Young Adults: A Case Series on the Hidden Dangers of Intravenous Drug Abuse in India.

Ann Afr Med
Prakash D, Balaji RV, Raguram R, Narayanan S, Janarthanan V, Kumaran S.   +5 more
europepmc   +1 more source

Psychometric properties of the modified Drug Abuse Screening Test Sinhala version (DAST-SL): evaluation of reliability and validity in Sri Lanka. [PDF]

BMC Public Health
Nawaratne SD, Vidanapathirana J.
europepmc   +1 more source

Prescribing competence: The pros and cons of different methods for assessment

British Journal of Clinical Pharmacology, EarlyView.
Evaluating a medical graduate’s competence in rational prescribing is challenging. With the aim to guide and inspire teachers, this narrative review explores different methods that can be used to assess prescribing competence. Each method has its own advantages and disadvantages, and thus a mix of different assessment methods is needed throughout the ...
David J. Brinkman, Erik M. Donker, Jelle Tichelaar, on behalf of the CP4T programme   +3 more
wiley   +1 more source

Association of Cigarette Smoking History With Drug Abuse History and Arterial Carboxyhemoglobin in Trauma Activation Patients: A Retrospective Study. [PDF]

Cureus
Dunham CM, Huang GS, Chance EA, Hileman BM.   +3 more
europepmc   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Effects of positive mGlu5 modulation on D₂ signaling and nicotine-conditioned place preference: Mechanisms of epigenetic inheritance in a transgenerational model of drug abuse vulnerability in psychosis. [PDF]

J Psychopharmacol
Peeters LD, Wills LJ, Cuozzo AM, Ahmed CD, Massey SR, Chen W, Chen Z, Wang C, Gass JT, Brown RW.   +9 more
europepmc   +1 more source

Using non‐linear slide decks to administer individualized problem‐based learning assessments within pharmacology education

British Journal of Clinical Pharmacology, EarlyView.
Aim Problem‐based learning (PBL) is an established approach in medical, nursing, pharmacy and veterinary medicine education. This study describes the implementation and aims to evaluate the use of non‐linear slide decks as a method to deliver PBL as individualized student assessments within pharmacology education. This approach, originally developed in
Wendy R. Francis, Nia A. Davies, Aidan Seeley   +2 more
wiley   +1 more source