Results 201 to 210 of about 435,266 (312)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Astrocytic G Protein-Coupled Receptors in Drug Addiction. [PDF]

open access: yesEngineering (Beijing)
Zinsmaier AK, Nestler EJ, Dong Y.
europepmc   +1 more source

Early life adversity: Epigenetic regulation underlying drug addiction susceptibility. [PDF]

open access: yesMol Cell Neurosci, 2023
Winter JJ   +3 more
europepmc   +1 more source

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