Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
"Loss of control" in alcoholism and drug addiction: A neuroscientific interpretation. [PDF]
, 2000 Michael Lyvers
openalex +3 more sources
Exploring the Relationship between Drug Addiction and Quality of Life in Herat, Afghanistan: A Cross-sectional Study. [PDF]
Addict Health, 2023 Shayan NA +4 more
europepmc +1 more source
Could a vaccine against the effects of cocaine be part of a treatment regimen for drug addiction? [PDF]
, 1996 openalex +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Helping Women Suffering from Drug Addiction: Needs, Barriers, and Challenges. [PDF]
Int J Environ Res Public Health, 2022 Motyka MA +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan +4 more
wiley +1 more source
Microglia in drug addiction: A perspective from neuroimmunopharmacology. [PDF]
Zool ResLin C, Wang X.
europepmc +1 more source
To Incarcerate or Not to Incarcerate: Is That the Right Question for Drug Addiction? [PDF]
Can J Psychiatry, 2022 Johnstone S +3 more
europepmc +1 more source