Results 91 to 100 of about 2,902,189 (362)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Simple and effective method for generating single-stranded DNA targets and probes

BioTechniques, 2006
A simple and efficient PCR method was developedfor generating dye- or radiolabeled single-stranded DNA targets or probes used for hybridization studies.
Xing Tang, Sheldon L. Morris, John J. Langone, Larry E. Bockstahler   +3 more
doaj   +1 more source

Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference. [PDF]

, 2013
Contextual cues associated with previous drug exposure can trigger drug craving and seeking, and form a substantial obstacle in substance use recovery.
Athilingam, Jegath, Muñoz-Cuevas, Francisco Javier, Piscopo, Denise, Wilbrecht, Linda   +3 more
core  

Optimal population-level infection detection strategies for malaria control and elimination in a spatial model of malaria transmission

, 2015
Mass campaigns with antimalarial drugs are potentially a powerful tool for local elimination of malaria, yet current diagnostic technologies are insufficiently sensitive to identify all individuals who harbor infections.
Bever, Caitlin A., Eckhoff, Philip A., Gerardin, Jaline, Hamainza, Busiku, Miller, John M., Wenger, Edward A.   +5 more
core   +3 more sources

Applying hierarchical task analysis to medication administration errors [PDF]

, 2006
Medication use in hospitals is a complex process and is dependent on the successful interaction of health professionals functioning within different disciplines.
Harrison, DJ, Lane, R, Stanton, NA
core   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

SANITATION AND THE FOOD AND DRUG ADMINISTRATION [PDF]

The author outlines the role of the Food and Drug Administration in Food MarketingMarketing,
Decamp, Philip
core   +1 more source

Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach [PDF]

, 2019
We introduce an agent-based model describing a susceptible-infectious-susceptible (SIS) system of humans and mosquitoes to predict malaria epidemiological scenarios in realistic biological conditions.
Lind, Pedro G., Louçã, Jorge, Mendes, António M., Sequeira, João   +3 more
core   +2 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source