Results 181 to 190 of about 2,902,189 (362)

Mass drug administration with azithromycin for trachoma elimination and the population structure of Streptococcus pneumoniae in the nasopharynx [PDF]

, 2020
Rebecca A. Gladstone, Ebrima Bojang, John Hart, Emma M. Harding‐Esch, David Mabey, Ansumana Sillah, Robin L. Bailey, Sarah E. Burr, Anna Roca, Stephen D. Bentley, Martin J. Holland   +10 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Community engagement in mass drug administration participatory interventions: A scoping review. [PDF]

PLoS Negl Trop Dis
Chouaïd A, Louart S, Faye A, Ba EH, Landier J, Ridde V.   +5 more
europepmc   +1 more source

Mucoadhesive In Situ Gelling Liquid Crystalline Precursor System to Improve the Vaginal Administration of Drugs

, 2019
Patricia Rocha de Araújo, Giovana Calixto, Isabel C. Silva, Lucas Henrique de Paula Zago, João Augusto Oshiro, Fernando R. Pavan, Anderson Orzari Ribeiro, Carla Raquel Fontana, Marlus Chorilli   +8 more
openalex   +2 more sources

Environmental resource footprinting of drug manufacturing : effects of scale up and drug administration [PDF]

, 2013
Boone, Lieselot, De Soete, Wouter, Dewulf, Jo, Heirman, Bert, Willemse, Filip   +4 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Reclaiming Rural Medicine: Mass Drug Administration, Community Sovereignty, and Institutional Memory. [PDF]

Cureus
Babul A, Mahdavi P, Hussain A, Janjua ZH, Hussain M.   +4 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Evaluating the effectiveness of mass drug administration on lymphatic filariasis transmission and assessment of post-mass drug administration surveillance in Nigeria's Federal Capital Territory. [PDF]

Infect Dis Poverty
Amanyi-Enegela JA, Kumbur J, Okunade F, Ashikeni D, Ishaya R, Sankar G, Adamani WE, Aderogba M, Makau-Barasa L, Emmanuel A, Ogundipe BE, Okoye C, Qureshi B.   +12 more
europepmc   +1 more source