Results 211 to 220 of about 7,897,516 (385)

The milk and food program of the Food and Drug Administration. [PDF]

, 1972
John H. Fritz
openalex   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Studies on Drug Metabolism. IV. Effects of High Dose Administration of Pentobarbital and Phenylbutazone on the Plasma Biologic Half Lives in Various Species

, 1968
Haruo Kitagawa, Tetsuya Kamataki, Soichi Yoshida   +2 more
openalex   +2 more sources

The effects of chronic drug administration on hepatic enzyme induction and folate metabolism. [PDF]

, 1978
Demetre Labadarios, JW Dickerson, DV Parke, EG Lucas, GH Obuwa   +4 more
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Racial Variations of the Injection Route of Administration among Injection Drug Users in the United States: A Comparative Trend Analysis

, 2019
The objective of this research is to address the variations in the injection route of administration among racial groups who are injection drug users in the United States and how that contributes to their vulnerability to HIV/AIDS behaviors and hospital ...
Danquah, Philip
core  

Studies on Drug Metabolism. II. : Changes of Sleeping Time, Liver Microsomal Drug Metabolizing Enzyme Activity and Accumulation to Various Organs by Long Term Administration (1 Month) of Pentobarbital in Cats

, 1968
Haruo Kitagawa, Soichi Yoshida, Tetsuya Kamataki   +2 more
openalex   +2 more sources

A STUDY OF THE FACTORS AFFECTING THE SLEEPING TIME FOLLOWING INTRACEREBROVENTRICULAR ADMINISTRATION OF PENTOBARBITONE SODIUM: EFFECT OF PRIOR ADMINISTRATION OF CENTRALLY ACTIVE DRUGS [PDF]

, 1974
Ian H. Stevenson, Michael J. Bull
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source