Results 221 to 230 of about 2,902,189 (362)

Strengthening the Food and Drug Administration Office of Clinical Pharmacology's Labeling Authority. [PDF]

Clin Transl Sci
Ratain MJ, Strohbehn GW.
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Real-world safety of Tepotinib: Insights from the Food and Drug Administration Adverse Event Reporting System. [PDF]

PLoS One
Wei S, Zhang L, Liu C, Qi X.
europepmc   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

US Food and Drug Administration Competitive Generic Therapy Approvals and Drug Competition.

JAMA Intern Med
Kho K, Patel R, Chahal HS.
europepmc   +1 more source

Medical Management of Obesity: A Comprehensive Review of Food and Drug Administration (FDA)-Approved and Investigational Therapies. [PDF]

Cureus
Raza SS, Zakir Z, Hashmat A, Awan SK, Varrassi G.   +4 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Long-term persistence of <i>Schistosoma mansoni</i> hotspots in western Kenya despite ongoing mass drug administration. [PDF]

Curr Res Parasitol Vector Borne Dis
Olilah P, Oguso J, Okinyo A, Le Clec'h W, Chevalier FD, Musembi S, Anderson T, Ndombi EM.   +7 more
europepmc   +1 more source

A Visual and Narrative Timeline Review of Spinal Cord Stimulation Technology and US Food and Drug Administration Milestones [PDF]

Johnson Ho, Cynthia Poon, Richard B. North, William Grubb, Scott F. Lempka, Marom Bikson   +5 more
openalex   +1 more source

A survey of the administration of drugs to young infants. The Alspac Survey Team. Avon Longitudinal Study of Pregnancy and Childhood. [PDF]

, 1995
Neil Hawkins, Jean Golding
openalex   +1 more source