Results 231 to 240 of about 7,897,516 (385)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Duration of Secretion of Bacteriostatic Drugs in Milk. I. Penicillin, Following Oral and Parenteral Administration

, 1962
R.Y. Cannon, George Hawkins, Anthony Wiggins   +2 more
openalex   +1 more source

A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2024. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Aksoyalp ZS, Kayki-Mutlu G, Wojnowski L, Michel MC.   +3 more
europepmc   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Microplanning improves stakeholders' perceived capacity and engagement to implement lymphatic filariasis mass drug administration. [PDF]

PLoS Negl Trop Dis
Worrell CM, Brant TA, Javel A, Denis E, Fayette C, Monestime F, Knowles E, Bennett C, Utzinger J, Odermatt P, Lemoine JF.   +10 more
europepmc   +1 more source

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

Hardly a Windfall: Prescribing Practices in Pediatric Heart Failure Around Food and Drug Administration Approval. [PDF]

JACC Adv
Ludomirsky AB, Edelson JB, Lin KY, Berger JH, O'Connor MJ, Wittlieb-Weber CA, Griffis H, Zhang B, Rossano JW.   +8 more
europepmc   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Biopharmaceutics of rectal administration of drugs in man [PDF]

, 1980
Frits Moolenaar
openalex   +1 more source

Evidence available and used by the Food and Drug Administration for the approval of orphan and nonorphan drugs. [PDF]

Health Aff Sch
Koong AJ, Irvin VL, Narayan A, Song S, Kaplan RM.   +4 more
europepmc   +1 more source