Results 51 to 60 of about 9,077,301 (404)
Evaluation of intranasal delivery route of drug administration for brain targeting.
Brain Research Bulletin, 2018 The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism, elimination, the unwanted side ...
F. Erdő +4 more
semanticscholar +1 more source
Oral Administration of Levo-Tetrahydropalmatine Attenuates Reinstatement of Extinguished Cocaine Seeking by Cocaine, Stress or Drug-Associated Cues in Rats [PDF]
, 2011 Cocaine addiction is characterized by a persistently heightened susceptibility to drug relapse. For this reason, the identification of medications that prevent drug relapse is a critical goal of drug abuse research.
Baker, David A. +9 more
core +2 more sources
Journal of Pharmacy and Science, 2019 This commentary provides an update on the status of physiologically based pharmacokinetic modeling and simulation at the U.S. Food and Drug Administration's Office of Clinical Pharmacology. Limitations and knowledge gaps in integration of physiologically
Manuela Grimstein +6 more
semanticscholar +1 more source
Frontiers in Microbiology, 2015 Vibrio parahaemolyticus is the leading cause of foodborne illnesses in the US associated with the consumption of raw shellfish. Previous population studies of V.
Julie eHaendiges +6 more
doaj +1 more source
Comparison of MiSeq, MinION, and hybrid genome sequencing for analysis of Campylobacter jejuni
Scientific Reports, 2021 The sequencing, assembly, and analysis of bacterial genomes is central to tracking and characterizing foodborne pathogens. The bulk of bacterial genome sequencing at the US Food and Drug Administration is performed using short-read Illumina MiSeq ...
Jason M. Neal-McKinney +4 more
doaj +1 more source
Sublingual Administration of Drugs [PDF]
Anesthesiology, 1944 In discussions of therapeutic technics there is frequently recurring opinion to the effect that any of the potent nonirritant drugs may be effectively administered by simple application to the oral mucosa. 1 Very few drugs, however, are routinely used in this way in regular practice.
openaire +1 more source
Frontiers in Pharmacology, 2016 Objectives: The recommended zolpidem starting dose was lowered in females (5mg vs 10mg) since side effects were more frequent and severe than those of males; the mechanism underlying sex differences in pharmacokinetics (PK) is unknown.
Cody J Peer +13 more
doaj +1 more source
Development of Drug-Device Combination Products and Generic Substitution in the United States
INNOVATIONS in PharmacyGeneric drug products approved and marketed in the United States include a variety of drug classes and dosage forms along with drug-device combination products (DDCPs).
YoonJung Lee +6 more
doaj +1 more source
Blood Cancer Journal, 2021 Over the past 13 years, there have been advances in characterizing the patient experience in oncology trials, primarily using patient-reported outcomes (PROs). This review aims to provide details on the PRO measures and analyses used in multiple myeloma (
Laura L. Fernandes +6 more
doaj +1 more source
The Price of Progress: Funding and Financing Alzheimer\u27s Disease Drug Development [PDF]
, 2018 Introduction Advancing research and treatment for Alzheimer\u27s disease (AD) and the search for effective treatments depend on a complex financial ecosystem involving federal, state, industry, advocacy, venture capital, and philanthropy funding ...
Cummings, Jeffrey +2 more
core +2 more sources