Results 1 to 10 of about 286,484 (191)

Characteristics of pediatric interventional drug trials registered between 2015 and 2024 on ClinicalTrials.gov [PDF]

Frontiers in Pediatrics
AimThis study comprehensively analyzed the characteristics and development trends of pediatric interventional drug clinical trials registered between 2015 and 2024, with a focus on pharmaceutical characteristics such as dosage form and administration ...
Yinghong Zhou, Zhaoxin Liu, Ji Xu, Ying Zhang, Haiqi Shen, Siyu Jiang, Yunyun Shi, Yinghua Lv, Jihan Huang   +8 more
doaj   +2 more sources

First-line management of canine status epilepticus at home and in hospital-opportunities and limitations of the various administration routes of benzodiazepines

BMC Veterinary Research, 2021
Status epilepticus (SE) or prolonged epileptic seizure activity is a common neurological emergency with a high mortality rate and, if left untreated, can lead to irreversible cerebral damage and systemic complications.
Marios Charalambous, Holger A. Volk, Luc Van Ham, Sofie F. M. Bhatti   +3 more
doaj   +1 more source

Patterns of Routes of Administration and Drug Tampering for Nonmedical Opioid Consumption: Data Mining and Content Analysis of Reddit Discussions

Journal of Medical Internet Research, 2021
BackgroundThe complex unfolding of the US opioid epidemic in the last 20 years has been the subject of a large body of medical and pharmacological research, and it has sparked a multidisciplinary discussion on how to implement interventions and policies ...
Balsamo, Duilio, Bajardi, Paolo, Salomone, Alberto, Schifanella, Rossano   +3 more
doaj   +1 more source

A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation

Plants, 2022
The use of cannabis and cannabinoid products for the treatment of neuropathic pain is a growing area of research. This type of pain has a high prevalence, limited response to available therapies and high social and economic costs.
Jose-Manuel Quintero, German Pulido, Luis-Fernando Giraldo, Marta-Ximena Leon, Luis-Eduardo Diaz, Rosa-Helena Bustos   +5 more
doaj   +1 more source

The effect of high-dose intramuscular epinephrine on the recovery of spontaneous circulation in an asphyxia‐induced cardiac arrest rat model

BMC Cardiovascular Disorders, 2021
Background Obtaining vascular access can be challenging during resuscitation following cardiac arrest, and it is particularly difficult and time-consuming in paediatric patients.
Daesung Lim, Soo Hoon Lee, Dong Hoon Kim, Changwoo Kang, Jin Hee Jeong, Sang Bong Lee   +5 more
doaj   +1 more source

Nanomedicine and versatile therapies for cancer treatment

MedComm, 2022
The higher prevalence of cancer is related to high rates of mortality and morbidity worldwide. By virtue of the properties of matter at the nanoscale, nanomedicine is proven to be a powerful tool to develop innovative drug carriers with greater ...
Aparna Shukla, Pralay Maiti
doaj   +1 more source

Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System

Frontiers in Pharmacology, 2022
Treatment of central nervous system (CNS) disorders is challenging using conventional delivery strategies and routes of administration because of the presence of the blood–brain barrier (BBB). This BBB restricts the permeation of most of the therapeutics
Manisha Pandey, Neha Jain, Jovita Kanoujia, Zahid Hussain, Bapi Gorain   +4 more
doaj   +1 more source

Pharmacokinetics and drug therapy in neonates [PDF]

Pediatric Emergency Medicine Journal, 2017
Neonates include both full term and preterm infants up to 28 days of age. The heterogeneity and rapid physiologic change of neonates affect all aspects of pharmacokinetics such as absorption, distribution, metabolism, and elimination. This feature should
Hye Jung Cho
doaj   +1 more source

Inhaled Insulin: Intrapulmonary or Intranasal? [PDF]

, 2012
Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Danish Ahmed, Shivangi Jaiswal, Shruti Mishra, Sweta Kumari   +3 more
core   +2 more sources

Alternative Routes of Administration for Therapeutic Antibodies—State of the Art

Antibodies, 2022
Background: For the past two decades, there has been a huge expansion in the development of therapeutic antibodies, with 6 to 10 novel entities approved each year.
Aubin Pitiot, Nathalie Heuzé-Vourc’h, Thomas Sécher   +2 more
doaj   +1 more source