Results 11 to 20 of about 101,859 (303)

First-line management of canine status epilepticus at home and in hospital-opportunities and limitations of the various administration routes of benzodiazepines

BMC Veterinary Research, 2021
Status epilepticus (SE) or prolonged epileptic seizure activity is a common neurological emergency with a high mortality rate and, if left untreated, can lead to irreversible cerebral damage and systemic complications.
Marios Charalambous, Holger A. Volk, Luc Van Ham, Sofie F. M. Bhatti   +3 more
doaj   +1 more source

A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation

Plants, 2022
The use of cannabis and cannabinoid products for the treatment of neuropathic pain is a growing area of research. This type of pain has a high prevalence, limited response to available therapies and high social and economic costs.
Jose-Manuel Quintero, German Pulido, Luis-Fernando Giraldo, Marta-Ximena Leon, Luis-Eduardo Diaz, Rosa-Helena Bustos   +5 more
doaj   +1 more source

The effect of high-dose intramuscular epinephrine on the recovery of spontaneous circulation in an asphyxia‐induced cardiac arrest rat model

BMC Cardiovascular Disorders, 2021
Background Obtaining vascular access can be challenging during resuscitation following cardiac arrest, and it is particularly difficult and time-consuming in paediatric patients.
Daesung Lim, Soo Hoon Lee, Dong Hoon Kim, Changwoo Kang, Jin Hee Jeong, Sang Bong Lee   +5 more
doaj   +1 more source

Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System

Frontiers in Pharmacology, 2022
Treatment of central nervous system (CNS) disorders is challenging using conventional delivery strategies and routes of administration because of the presence of the blood–brain barrier (BBB). This BBB restricts the permeation of most of the therapeutics
Manisha Pandey, Neha Jain, Jovita Kanoujia, Zahid Hussain, Bapi Gorain   +4 more
doaj   +1 more source

Nanomedicine and versatile therapies for cancer treatment

MedComm, 2022
The higher prevalence of cancer is related to high rates of mortality and morbidity worldwide. By virtue of the properties of matter at the nanoscale, nanomedicine is proven to be a powerful tool to develop innovative drug carriers with greater ...
Aparna Shukla, Pralay Maiti
doaj   +1 more source

Pharmacokinetics and drug therapy in neonates [PDF]

Pediatric Emergency Medicine Journal, 2017
Neonates include both full term and preterm infants up to 28 days of age. The heterogeneity and rapid physiologic change of neonates affect all aspects of pharmacokinetics such as absorption, distribution, metabolism, and elimination. This feature should
Hye Jung Cho
doaj   +1 more source

Alternative Routes of Administration for Therapeutic Antibodies—State of the Art

Antibodies, 2022
Background: For the past two decades, there has been a huge expansion in the development of therapeutic antibodies, with 6 to 10 novel entities approved each year.
Aubin Pitiot, Nathalie Heuzé-Vourc’h, Thomas Sécher   +2 more
doaj   +1 more source

Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations

Pharmaceutics, 2020
The treatment of the posterior-segment ocular diseases, such as age-related eye diseases (AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the complex anatomy and physiology of the eye. This specialized organ is composed
Rubén Varela-Fernández, Victoria Díaz-Tomé, Andrea Luaces-Rodríguez, Andrea Conde-Penedo, Xurxo García-Otero, Asteria Luzardo-Álvarez, Anxo Fernández-Ferreiro, Francisco J. Otero-Espinar   +7 more
doaj   +1 more source

Drug Bioavailability Enhancing Agents of Natural Origin (Bioenhancers) that Modulate Drug Membrane Permeation and Pre-Systemic Metabolism

Pharmaceutics, 2019
Many new chemical entities are discovered with high therapeutic potential, however, many of these compounds exhibit unfavorable pharmacokinetic properties due to poor solubility and/or poor membrane permeation characteristics. The latter is mainly due to
Bianca Peterson, Morné Weyers, Jan H. Steenekamp, Johan D. Steyn, Chrisna Gouws, Josias H. Hamman   +5 more
doaj   +1 more source

Contribution of Particle Design Research to the Development of Patient-Centric Dosage Forms

KONA Powder and Particle Journal, 2021
A variety of dosage forms have been developed in order to achieve effective and safe drug delivery in topical or systemic drug administrations. In this review, formulation research and process issues related to a popular oral dosage form, the tablet, are
Hirofumi Takeuchi
doaj   +1 more source