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Influences of formulations and administration routes on docetaxel tissue distribution in mice. [PDF]
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2018
Systemic absorption of a drug depends on its physicochemical properties, the nature of the dosage form on which it is included and the anatomical and physiological characteristics of the site of absorption. These considerations are important on the biopharmaceutical production and evaluation of drugs: the design of the dosage forms requires a deep ...
Ruiz, María Esperanza +1 more
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Systemic absorption of a drug depends on its physicochemical properties, the nature of the dosage form on which it is included and the anatomical and physiological characteristics of the site of absorption. These considerations are important on the biopharmaceutical production and evaluation of drugs: the design of the dosage forms requires a deep ...
Ruiz, María Esperanza +1 more
+5 more sources
Route of Administration and Drug Disposition
Drug Metabolism Reviews, 1975(1975). Route of Administration and Drug Disposition. Drug Metabolism Reviews: Vol. 3, No. 1, pp. 185-199.
M, Gibaldi, D, Perrier
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Route of administration and drug metabolism
European Journal of Pharmacology, 1972Abstract Studies with ‘first-pass’ pharmacokinetic models have revealed a number of interesting characteristics in regard to the influence of route of administration on drug and metabolite levels in the tissue, the % of dose excreted in the urine as unchanged drug and the composition of total metabolites in the urine.
M, Gibaldi, S, Feldman
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Drug administration during CPR: What route?
Resuscitation, 1991There has been considerable controversy regarding the optimum route of administration of drugs during cardiopulmonary resuscitation (CPR). Much of the confusion has arisen because the results of investigations in animals have been extrapolated to CPR in man. This may be inappropriate for a number of reasons.
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Effect of route of administration on drug disposition
Journal of Pharmacokinetics and Biopharmaceutics, 1972An increasing body of information tends to support the hypothesis that drug effect, therapeutic or toxic, is more closely correlated with plasma concentration than dose (Levy, 1968). Absorption is one important determinant of drug plasma levels. Distribution and elimination are others.
S, Riegelman, M, Rowland
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