Results 271 to 280 of about 577,363 (331)
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Pharmaceutics and Routes of Drug Administration
2013All medicines must be administered as prescribed and following the manufacturers’ guidance. The main aim of medicines management is to achieve the desired therapeutic effect for the patient. In order to do this you need to:… ● give the correct medicine, ● at the correct dose, ● to the correct person, ● in the correct formulation, ● by the correct route,
Graham Brack +2 more
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Routes of Administration and Drug Response
1975The route of administration for a drug should be selected to achieve an effective concentration at the site of action as conveniently as possible. Important subsidiary objectives may be rapidity of onset and duration of drug effect and, in some instances, selectivity of action.
D. S. Davies, C. T. Dollery
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Influence of Route of Administration on Drug Availability
Journal of Pharmaceutical Sciences, 1972In therapeutics, dose requirements are sometimes larger for a drug given orally than are needed following parenteral administration. This might be the case despite complete and rapid absorption of the drug and arises when a large fraction of the oral dose is eliminated on first passage through the liver. The basis of determining clearance from the area
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Challenges Associated with Route of Administration in Neonatal Drug Delivery [PDF]
Clinical Pharmacokinetics, 2015 The administration of drugs to neonates poses significant challenges. The aim of this review was to provide insight into some of these challenges and resolutions that may be encountered with several of the most commonly used routes of administration and dosage forms in neonatal care, including oral, parenteral, transdermal, intrapulmonary, and rectal ...
Linakis, Matthew W. +7 more
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Principles of Drug Absorption and Routes of Administration
1981We will deal here with the process of drug absorption from different sites in the body. Drug absorption, whether it be from the gastro-intestinal tract or from the buccal mucosa, requires the passage of the drug in a molecular form across the barrier membrane.
A. T. Florence, D. Attwood
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A REVIEW ON BUCCAL MUCOSAL ROUTE OF DRUG ADMINISTRATION
INDIAN DRUGS, 2016Oral route is the most preferred rote of drug administration. In oral route buccal mucosal route is one of the advantageous routes of drug administration. This route provides direct access to systemic circulation through the jugular vein, bypassing the first pass hepatic metabolism, which leads to high bioavailability.
G Bhatt +3 more
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Effect of route of administration and distribution on drug action
Journal of Pharmacokinetics and Biopharmaceutics, 1978The extent and time course of drug action can be markedly affected by the route of drug administration into the patient as well as the pattern of drug distribution within the patient. Drugs which are rapidly cleared by hepatic processes will show a decreased extent of availability following oral administration due to metabolism of drug on its first ...
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Influence of route of hepatic administration on drug availability.
The Journal of Pharmacology and Experimental Therapeutics, 1984The work investigates functional variability of hepatic arterial and portal venous streams in relation to drug availability. In an isolated rat liver system perfused in all experiments at a constant total flow of 10 ml X min-1, drug availability was found to be 18 and 3 times greater for lidocaine and meperidine, respectively, when infused through the ...
A B, Ahmad, P N, Bennett, M, Rowland
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Drug administration during CPR: What route?
Resuscitation, 1991There has been considerable controversy regarding the optimum route of administration of drugs during cardiopulmonary resuscitation (CPR). Much of the confusion has arisen because the results of investigations in animals have been extrapolated to CPR in man. This may be inappropriate for a number of reasons.
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