Results 41 to 50 of about 286,603 (310)

Advancements in Nanoemulsion-Based Drug Delivery Across Different Administration Routes

Pharmaceutics
Nanoemulsions (NEs) have emerged as effective drug delivery systems over the past few decades due to their multifaceted nature, offering advantages such as enhanced bioavailability, protection of encapsulated compounds, and low toxicity.
Maria D. Chatzidaki, Evgenia Mitsou
doaj   +1 more source

Comparison of efficacy of different route of administration of chemotherapy on unresectable, advanced gastric cancer

World Journal of Surgical Oncology, 2012
Background The aim of this study was to compare the efficacy of two neoadjuvant chemotherapies (FLEEOX and XELOX) with different routes of administration for unresectable gastric cancer.
Zhang Caihua, Li Guoli, Fan Chaogang, Xu Jian, Cao Jianmin, Liu Shen, Li Ning   +6 more
doaj   +1 more source

Caspofungin-Induced Cardiotoxicity in Patients Treating for Candidemia

Toxics, 2022
Echinocandins selectively inhibit fungal cell wall synthesis and, therefore, have few side effects. However, there are reports of hemodynamic and cardiac complications.
Roya Sattarzadeh Badkoubeh, Mostafa Farajpour, Mohammadreza Salehi, Alborz Sherafati, Zahra Zamani, Omid Rezahosseini, Pejman Mansouri, Akram Sardari   +7 more
doaj   +1 more source

Implications of subcutaneous or intravenous delivery of trastuzumab: further insight from patient interviews in the PrefHer study [PDF]

, 2015
BACKGROUND: The 2 Cohort randomised PrefHer trial examined the preferences of HER2+ve primary breast cancer patients for intravenous (IV) or subcutaneous (SC) delivery of trastuzumab via a Single Injectable Device (SID) or hand-held syringe (HHS).
Basch, C. Langridge, Ismael, J. Kilkerr, K. Monson, L. Fallowfield, Melichar, Piccart-Gebhart, Pivot, Pivot, S. Osborne, Samanta, Slamon, Stoner, V. Jenkins   +14 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Recreational use, analysis and toxicity of tryptamines [PDF]

, 2015
The definition New psychoactive substances (NPS) refers to emerging drugs whose chemical structures are similar to other psychoactive compounds but not identical, representing a "legal" alternative to internationally controlled drugs.
Mannocchi, Giulio, Pantano, Flaminia, Romolo, Francesco Saverio, Tittarelli, Roberta   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Importance of Nanoparticles for the Delivery of Antiparkinsonian Drugs

Pharmaceutics, 2021
Parkinson’s disease (PD) affects around ten million people worldwide and is considered the second most prevalent neurodegenerative disease after Alzheimer’s disease. In addition, there is a higher risk incidence in the elderly population.
Sara Silva, António J. Almeida, Nuno Vale   +2 more
doaj   +1 more source

From clinical application to cognitive enhancement: the example of methylphenidate [PDF]

, 2016
Methylphenidate (MPD) is a central nervous system (CNS) stimulant, which belongs to the phenethylamine group and is mainly used in the treatment of attention deficit hyperactive disorder (ADHD).
Busardo', FRANCESCO PAOLO, Cipolloni, Luigi, Frati, Paola, Kyriakou, Chrystalla, Zaami, Simona   +4 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source