Results 41 to 50 of about 577,363 (331)

Pharmacokinetic Comparison of Three Different Administration Routes for Topotecan Hydrochloride in Rats

Pharmaceuticals, 2020
Topotecan is actively used in clinic, with its primary use being in treatment of various types of cancer. The approved administration routes are oral and intravenous.
Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee   +2 more
doaj   +1 more source

Preparation Strategies of the Anti-Mycobacterial Drug Bedaquiline for Intrapulmonary Routes of Administration

Pharmaceuticals, 2023
Mycobacterium tuberculosis (M.tb) has infected one-quarter of the world’s population and led to the deaths of 1.6 million individuals in 2021 according to estimates from the World Health Organization.
Sara E. Maloney, Ian E. Stewart, Brendan K. Podell, Hadley E. Gary, Jeffrey B. Mecham, Bryan J. Berube, Susan L. Baldwin, Rhea N. Coler, Anthony J. Hickey   +8 more
doaj   +1 more source

Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models

Pharmaceuticals
Drugs administered by means of extravascular routes of drug administration must be absorbed into the systemic circulation, which involves the movement of the drug molecules across biological barriers such as epithelial cells that cover mucosal surfaces ...
Johan D. Steyn, Anja Haasbroek-Pheiffer, Wihan Pheiffer, Morné Weyers, Suzanne E. van Niekerk, Josias H. Hamman, Daniélle van Staden   +6 more
doaj   +1 more source

Falsely elevated serum testosterone measurements resulting from testosterone topical gel contamination of the venipuncture site: Case Series and retrospective review

Heliyon, 2023
Testosterone as replacement therapy for male hypogonadism or as gender-affirming hormone therapy for transgender and non-binary patients has increased worldwide.
Aranza Pinedo Pichilingue, Dina N. Greene, Matthew D. Krasowski   +2 more
doaj   +1 more source

Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

Pharmaceutics, 2023
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications.
Nimeet Desai, Dhwani Rana, Sagar Salave, Raghav Gupta, Pranav Patel, Bharathi Karunakaran, Amit Sharma, J. Giri, Derajram Benival, Nagavendra Kommineni   +9 more
semanticscholar   +1 more source

Carrier Systems for Advanced Drug Delivery: Improving Drug Solubility/Bioavailability and Administration Routes

Pharmaceutics
The disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led to the rational design of drug delivery systems.
Sonia Losada-Barreiro, Sumeyye Celik, Zerrin Sezgin-Bayindir, Sofía Bravo-Fernández, Carlos Bravo-Díaz   +4 more
doaj   +1 more source

Caspofungin-Induced Cardiotoxicity in Patients Treating for Candidemia

Toxics, 2022
Echinocandins selectively inhibit fungal cell wall synthesis and, therefore, have few side effects. However, there are reports of hemodynamic and cardiac complications.
Roya Sattarzadeh Badkoubeh, Mostafa Farajpour, Mohammadreza Salehi, Alborz Sherafati, Zahra Zamani, Omid Rezahosseini, Pejman Mansouri, Akram Sardari   +7 more
doaj   +1 more source

Curcumin Administration Routes in Breast Cancer Treatment

International Journal of Molecular Sciences
Breast cancer is a public health concern worldwide, characterized by increasing incidence and mortality rates, requiring novel and effective therapeutic strategies.
Bianca Mayo, Silvana Penroz, Keila Torres, L. Simón   +3 more
semanticscholar   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Importance of Nanoparticles for the Delivery of Antiparkinsonian Drugs

Pharmaceutics, 2021
Parkinson’s disease (PD) affects around ten million people worldwide and is considered the second most prevalent neurodegenerative disease after Alzheimer’s disease. In addition, there is a higher risk incidence in the elderly population.
Sara Silva, António J. Almeida, Nuno Vale   +2 more
doaj   +1 more source