Results 211 to 220 of about 152,098 (264)

Second-order schedules of drug self-administration in animals

Psychopharmacology, 2002
On a second-order schedule, a subject responds according to one schedule (the unit schedule) for a brief presentation of a stimulus such as a light. Responding by the subject on this unit schedule is then reinforced according to another schedule of reinforcement.
Charles W, Schindler, Leigh V, Panlilio, Steven R, Goldberg   +2 more
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Fixed-interval schedules for drug self-administration in the rat

Psychopharmacology, 1989
The practicality of using second-order fixed-interval schedules in studies of heroin reinforcement with rats was examined. Optimum rates of responding were obtained with a dose of 0.03 mg/kg/infusion and an interval duration of 3 min. In addition, schedules consisting of a only a single interval were shown to be practical, leading to response rates ...
W A, Corrigall, K M, Coen
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Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review

Psychopharmacology, 1998
Drugs, like other reinforcers, can vary in their relative abilities to support operant responding. Considerable research has been designed to obtain useful measures of a given drug's or dose's "reinforcing efficacy" and to identify the ways in which a variety of behavioral and pharmacological variables impact these measures. Progressive-ratio schedules
D, Stafford, M G, LeSage, J R, Glowa
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Drug Self-Administration by Laboratory Animals: Control by Schedules of Reinforcement

Annual Review of Pharmacology and Toxicology, 1978
A common factor underlying all concepts of drug dependence is the persistent maintenance of behavior that leads to drug self-administration (I, 2). Early studies of drug self-administration by laboratory animals involved morphine and employed subjects that were made physiologically (physically) dependent by repeated injec­ tions prior to the initiation
R D, Spealman, S R, Goldberg
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Drug self-administration studies

Behavioural Pharmacology, 2013
Relative reinforcing effects of different ethanol and different cocaine doses were studied under concurrent independent fixed-ratio (FR) schedules and concurrent nonindependent FR schedules with rhesus monkeys. Nonindependent FR schedules differed from independent FR schedules in that responses on either side counted towards the FR requirements of two ...
Richard A, Meisch, Thomas H, Gomez
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Second-order schedules of intravenous drug self-administration in rhesus monkeys

Pharmacology Biochemistry and Behavior, 1977
Lever-pressing behavior was generated and maintained in 3 rhesus monkeys by intravenous infusions of morphine or cocaine under a second-order schedule of reinforcement. Under this schedule, every tenth lever-press response (FR 10) during a fixed interval of time produced a 2 sec stimulus light.
J R, Sanchez-Ramos, C R, Schuster
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The Influence of Dose Schedules and Administration Routes on the Toxicity of Potential Antiviral Drugs

1984
The influence of two differently constructed dose schedules and of two dissimilar administration routes on the subacute toxicity of the potential antiviral drug benzoxazolyl-2-formyl-S-ethyl-isothiosemicarbazone was investigated in mice. Administration of identical aliquots of the, route dependent, maximally tolerated, dose was found to cause no ...
R, Amlacher, H, Hoffmann
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Effects of drugs on schedule-controlled behavior in rats during chronic haloperidol administration.

The Journal of Pharmacology and Experimental Therapeutics, 1985
Dose-response curves for haloperidol, phencyclidine, morphine, meperidine and cimetidine were determined in rats trained under a multiple fixed-ratio 30, fixed-interval 5-min schedule of reinforcement. Haloperidol, morphine, meperidine and cimetidine decreased both fixed-ratio and fixed-interval rates of responding.
S K, Rastogi, D E, McMillan
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SCHEDULE OF HORMONAL DRUGS ADMINISTRATION TO FEMALE RABBITS FOR THE ENHACEMENT OF ARTIFICIAL INSEMINATION

Естественные и технические науки, 2020
В данной статье рассматриваются результаты исследования по использованию гормональных препаратов в определённом режиме с целью контроля и управления репродуктивными функциями млекопитающих при искусственном осеменении на примере кроликов. The article discusses the results of hormonal drugs ...
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Schedule-induced drug self-administration

1993
Publisher Summary This chapter describes schedule-induced drug self-administration. The characteristics of schedule-induced behavior bear some similarities to the behavioral features of drug abuse. Both are chronically excessive sorts of behavior with powerful motivational efficacies.
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