Results 91 to 100 of about 172,588 (315)
PLoS ONE, 2020 Calcific aortic valve disease (CAVD) is a deadly disease that is rising in prevalence due to population aging. While the disease is complex and poorly understood, one well-documented driver of valvulopathy is serotonin agonism.
J Ethan Joll +5 more
doaj +1 more source
Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]
, 2009 Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan +4 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
In vitro inhibitory effect of tacrolimus combined with antifungal agents on Candida species [PDF]
精准医学杂志Objective To investigate the in vitro inhibitory effect of tacrolimus (TAC) combined with fluconazole (FLC), voriconazole (VRC), amphotericin B (AMB) or caspofungin (CAS) on Candida species. Methods Candida albicans, Candida tropicalis, Candida glabrata,
ZANG Ying, GE Hongfen, WANG Yingying, LU Jinming, LIU Yanfei, CHEN Juan, WANG Jun
doaj +1 more source
The Genetic and Environmental Sources of Resemblance Between Normative Personality and Personality Disorder Traits [PDF]
, 2017 Recent work has suggested a high level of congruence between normative personality, most typically represented by the big five factors, and abnormal personality traits.
Aggen, S. H. +8 more
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes [PDF]
, 2018 The realisation of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (M1 mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating ...
Bradley, Sophie J. +14 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Evaluation of Drug Interactions and Prescription Errors of Poultry Veterinarians in North of Iran [PDF]
Poultry Science Journal, 2014 Drug prescription errors are a common cause of adverse incidents and may lead to adverse outcomes, sometimes in subtle ways, being compounded by circumstances or further errors.
Madadi MS, Bojmehrani H, Azari M
doaj
Guided screen for synergistic three-drug combinations.
PLoS ONE, 2020 Combinations of three or more drugs are routinely used in various medical fields such as clinical oncology and infectious diseases to prevent resistance or to achieve synergistic therapeutic benefits.
Melike Cokol-Cakmak +4 more
doaj +1 more source