Network-driven prioritization and functional phenotyping nominate TTC23 as a biomarker-informed target in chlorpromazine repurposing for glioblastoma [PDF]
Frontiers in PharmacologyBackgroundGlioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options and near-universal recurrence. Drug repurposing offers a practical strategy, but pleiotropic compounds require systematic target triage to yield actionable and ...
Jianqiang Hao +5 more
doaj +2 more sources
Analysis of Pharmacokinetic and Pharmacodynamic Interactions Between Chlorpromazine and Risperidone via Simultaneous Measurement of Multiple Receptor Occupancy in the Rat Brain [PDF]
BiomedicinesBackground/Objectives: Combination therapy for schizophrenia may exacerbate side effects mediated by multiple brain receptors. This study aimed to elucidate the pharmacodynamic and pharmacokinetic interactions between chlorpromazine and risperidone.
Gaku Akashita +3 more
doaj +2 more sources
Evaluation of the use of chlorpromazine for agitation in pediatric patients [PDF]
Mental Health Clinician, 2023 Introduction: Chlorpromazine is a first-generation antipsychotic used for behavioral problems in pediatric patients. However, other therapies may demonstrate both improved outcomes and fewer side effects.
Rajwoana Ahmed, PharmD +4 more
doaj +1 more source
Kufa Journal for Veterinary Medical Sciences, 2021 The goal of this study was to assess the pain-relieving action of tramadol alone or when administered with chlorpromazine and screening for analgesic effects by using sedative non-analgesic doses of tramadol and chlorpromazine when injected together in
Manahel Allawi Abdulla Aljbori +2 more
doaj +1 more source
Coated Wire and Multiwalled Carbon Nanotube Composite Coated Wire Sensors for Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations. [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2014 fabrication and performance characteristics of novel potentiometric sensors for the determination of chlorpromazine hydrochloride are described. The proposed sensors include a coated copper wire sensor and a multiwalled carbon nanotube (MWCNT) composite ...
Riyadh M. Jihad +2 more
doaj +1 more source
Quincke-edema induced by chlorpromazine: About two cases
European Psychiatry, 2021 Introduction Quincke-edema has been specifically associated with using certain drugs including chlorpromazine as detailed through two clinical cases. Objectives Illustration of two clinical cases about angioedema induced by Chlorpromazine.
S. Brahim +4 more
doaj +1 more source
Borneo Journal of Pharmacy, 2021 Schizophrenia is a psychiatric disorder that requires antipsychotics therapy. Antipsychotics cause many side effects, including orthostatic hypotension.
Noor Cahaya +2 more
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Short–term effect of chlorpromazine and diazepam on blood plasma acetylcholinesterase activity in chicks [PDF]
Iraqi Journal of Veterinary Sciences, 2007 The response of blood plasma acetylcholinestrase to acute administration of chlorpromazine and diazepam was examined in chick. Chlorpromazine in a dose–dependent manner at 25, 50, and 75 mg/Kg, subcutaneously inhibited the activity of Ache in the blood ...
L .K. Yacoub
doaj +1 more source
Intravenous chlorpromazine in the acute treatment of episodic tension-type headache: a randomized, placebo controlled, double-blind study [PDF]
Arquivos de Neuro-Psiquiatria, 2002 Acute headache is a very frequent symptom, responsible for a significant percentage of caseload at primary care units and emergency rooms. Chlorpromazine is easily available in such settings.
Marcelo Eduardo Bigal +2 more
doaj +1 more source
Frontiers in Oncology, 2023 IntroductionDrug repurposing is a promising strategy to develop new treatments for glioblastoma. In this phase II clinical trial, we evaluated the addition of chlorpromazine to temozolomide in the adjuvant phase of the standard first-line therapeutic ...
Andrea Pace +14 more
doaj +1 more source