Results 1 to 10 of about 50,664 (197)
Longitudinal Gut Microbiota Dysbiosis Underlies Olanzapine-Induced Weight Gain
Microbiology Spectrum, 2023 Olanzapine is one of the most effective medicines available for stabilizing schizophrenia spectrum disorders. However, it has been reported to show the greatest propensity for inducing body weight gain and producing metabolic side effects, which cause a ...
Li Qian +10 more
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High-dose olanzapine versus standard-dose olanzapine: Effect on all-cause readmission rates in adult psychiatric patients [PDF]
Mental Health ClinicianIntroduction Olanzapine doses in adults with treatment-resistant schizophrenia or treatment-resistant schizoaffective disorder have been compared in a few open-label trials, with higher doses associated with increased symptom improvement.
Teressa Benbarka, PharmD +1 more
doaj +2 more sources
Effect of age, sex, and BMI on serum olanzapine levels and their correlation with metabolic parameters and serum pro-inflammatory cytokine levels in schizophrenia patients [PDF]
BMC PsychiatryObjective Olanzapine is an atypical antipsychotic drug which is effective in the treatment of schizophrenia (SCZ). Olanzapine exhibits significant pharmacokinetic variability and is associated with a higher propensity for metabolic abnormalities.
Wenfan Gao +5 more
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Olanzapine-induced lipid disturbances: A potential mechanism through the gut microbiota-brain axis
Frontiers in Pharmacology, 2022 Objective: Long-term use of olanzapine can induce various side effects such as lipid metabolic disorders, but the mechanism remains to be elucidated. The gut microbiota-brain axis plays an important role in lipid metabolism, and may be related to the ...
Zhenyu Zhu +7 more
semanticscholar +1 more source
Frontiers in Neuroscience, 2021 The antipsychotic drug olanzapine is associated with serious obesity side effects. Hypothalamic astrocytes and associated toll-like receptor-4 (TLR4) signaling play an essential role in obesity pathogenesis.
Meng He +9 more
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A case report and literature review of olanzapine-associated hyperglycemia with previous history of gestational diabetes [PDF]
Mental Health Clinician, 2022 Background: Olanzapine (Zyprexa) package labeling includes a warning for hyperglycemia, stating physicians should consider the risks and benefits when prescribing olanzapine to patients with an established diagnosis of diabetes mellitus or having ...
Jennifer N. Alastanos, PharmD, BCPP, BCPS +3 more
doaj +1 more source
The gut microbiome influences the bioavailability of olanzapine in rats
EBioMedicine, 2021 Background The role of the gut microbiome in the biotransformation of drugs has recently come under scrutiny. It remains unclear whether the gut microbiome directly influences the extent of drug absorbed after oral administration and thus potentially ...
S. Cussotto +11 more
semanticscholar +1 more source
Scientific Reports, 2021 This study compared weight and cardiometabolic changes after short-term treatment of olanzapine/samidorphan and olanzapine. Eligible criteria for an included trial were ≤ 24 weeks, randomized controlled trials (RCTs) that compared olanzapine/samidorphan ...
Manit Srisurapanont +4 more
doaj +1 more source
Olanzapine leads to nonalcoholic fatty liver disease through the apolipoprotein A5 pathway
bioRxiv, 2021 The antipsychotic drug olanzapine was reported to induce nonalcoholic fatty liver disease (NAFLD), whereas the underlying mechanism remains incompletely understood.
Rong Li +8 more
semanticscholar +1 more source
Frontiers in Oncology, 2021 IntroductionThe aim of this study is to rigorously review the efficacy and safety of olanzapine in chemotherapy-induced nausea and vomiting (CINV) settings including (1) at 5- and 10-mg doses, and (2) the setting of highly emetogenic chemotherapy (HEC ...
Dong-Yang Wang +3 more
doaj +1 more source