Results 1 to 10 of about 56,178 (231)

A case report and literature review of olanzapine-associated hyperglycemia with previous history of gestational diabetes [PDF]

Mental Health Clinician, 2022
Background: Olanzapine (Zyprexa) package labeling includes a warning for hyperglycemia, stating physicians should consider the risks and benefits when prescribing olanzapine to patients with an established diagnosis of diabetes mellitus or having ...
Jennifer N. Alastanos, PharmD, BCPP, BCPS, Devika Suri, PharmD, Hayato DeLellis, PharmD, Andrea Mapugay, PharmD   +3 more
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Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain

Frontiers in Neuroscience, 2021
The antipsychotic drug olanzapine is associated with serious obesity side effects. Hypothalamic astrocytes and associated toll-like receptor-4 (TLR4) signaling play an essential role in obesity pathogenesis.
Meng He, Kun Qian, Ying Zhang, Xu-Feng Huang, Chao Deng, Baohua Zhang, Guanbin Gao, Jing Li, Hao Xie, Taolei Sun   +9 more
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A meta-analysis comparing short-term weight and cardiometabolic changes between olanzapine/samidorphan and olanzapine

Scientific Reports, 2021
This study compared weight and cardiometabolic changes after short-term treatment of olanzapine/samidorphan and olanzapine. Eligible criteria for an included trial were ≤ 24 weeks, randomized controlled trials (RCTs) that compared olanzapine/samidorphan ...
Manit Srisurapanont, Sirijit Suttajit, Surinporn Likhitsathian, Benchalak Maneeton, Narong Maneeton   +4 more
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Alterations in sorting and secretion of hepatic apoA5 induce hypertriglyceridemia due to short-term use of olanzapine

Frontiers in Pharmacology, 2022
Long-term use of olanzapine, an antipsychotic drug, induces hypertriglyceridemia, resulting in a higher risk of cardiovascular disease. However, the effects and underlying mechanisms of short-term use of olanzapine on circulating triglyceride levels ...
Piao-Piao Huang, Piao-Piao Huang, Wen-Qiang Zhu, Wen-Qiang Zhu, Jing-Mei Xiao, Yi-Qi Zhang, Rong Li, Yang Yang, Yang Yang, Li Shen, Li Shen, Fei Luo, Fei Luo, Fei Luo, Wen Dai, Wen Dai, Wen Dai, Ping-An Lian, Ping-An Lian, Ya-Xin Tang, Ya-Xin Tang, Juan-Li Ran, Xian-Sheng Huang, Xian-Sheng Huang   +23 more
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The Balance Between the Effectiveness and Safety for Chemotherapy-Induced Nausea and Vomiting of Different Doses of Olanzapine (10 mg Versus 5 mg): A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2021
IntroductionThe aim of this study is to rigorously review the efficacy and safety of olanzapine in chemotherapy-induced nausea and vomiting (CINV) settings including (1) at 5- and 10-mg doses, and (2) the setting of highly emetogenic chemotherapy (HEC ...
Dong-Yang Wang, Yi Chen, You Zhang, Ying-Qiang Shen   +3 more
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CYP1A2 expression rather than genotype is associated with olanzapine concentration in psychiatric patients

Scientific Reports, 2023
Olanzapine is a commonly prescribed atypical antipsychotic agent for treatment of patients with schizophrenia and bipolar disorders. Previous in vitro studies using human liver microsomes identified CYP1A2 and CYP2D6 enzymes being responsible for CYP ...
Ferenc Fekete, Ádám Menus, Katalin Tóth, Ádám Ferenc Kiss, Annamária Minus, Dávid Sirok, Aleš Belič, Ádám Póti, Gábor Csukly, Katalin Monostory   +9 more
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Longitudinal Gut Microbiota Dysbiosis Underlies Olanzapine-Induced Weight Gain

Microbiology Spectrum, 2023
Olanzapine is one of the most effective medicines available for stabilizing schizophrenia spectrum disorders. However, it has been reported to show the greatest propensity for inducing body weight gain and producing metabolic side effects, which cause a ...
Li Qian, Xiaoyan He, Yixin Liu, Fengjie Gao, Wen Lu, Yajuan Fan, Yuan Gao, Wei Wang, Feng Zhu, Yanan Wang, Xiancang Ma   +10 more
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Rare and Underestimated Association of Pulmonary Embolism and Olanzapine Therapy; Report of Two Cases

Archives of Academic Emergency Medicine, 2021
: Venous thromboembolic disease (VTD) is a very common and severe pathological condition in which there are many predisposing factors. Olanzapine is a drug frequently used in psychiatric practises; it is thought to increase the risk of VTD.
Hammam Rasras, Mustapha Beghi, Maryem Samti, Nabila Ismaili, Noha El Ouafi   +4 more
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Physiologically‐Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan

CPT: Pharmacometrics & Systems Pharmacology, 2020
A combination of the antipsychotic olanzapine and the opioid receptor antagonist samidorphan (OLZ/SAM) is intended to provide the antipsychotic efficacy of olanzapine while mitigating olanzapine‐associated weight gain.
Lei Sun, Lisa vonMoltke, Karen Rowland Yeo   +2 more
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Long-term administration of olanzapine induces adiposity and increases hepatic fatty acid desaturation protein in female C57BL/6J mice [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic effects of chronic olanzapine exposure.
Po-Hsun Hou, Geng-Ruei Chang, Chin-Pin Chen, Yen-Ling Lin, I-Shuan Chao, Ting-Ting Shen, Frank Mao   +6 more
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